2. Gene
  3. RGL3 - ral guanine nucleotide dissociation stimulator like 3 Gene

RGL3 - ral guanine nucleotide dissociation stimulator like 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 57139 | Gene type: protein coding

About RGL3

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:11,394,060-11,419,314 (from NCBI)

This gene has 17 transcripts (splice variants), 96 orthologues and 24 paralogues. Broad expression in thyroid (RPKM 19.9), kidney (RPKM 13.4) and 17 other tissues.

Summary

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in positive regulation of GTPase activity and small GTPase mediated signal transduction. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

RGL3 Products(2)

mRNA Protein Name
NM_001035223.4 NP_001030300.3 ral guanine nucleotide dissociation stimulator-like 3 isoform 2
NM_001161616.3 NP_001155088.2 ral guanine nucleotide dissociation stimulator-like 3 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGL3 Protein Structure

RasGEF_N

RasGEF_N: RasGEF N-terminal motif (69 - 164)

RasGEF

RasGEF: RasGEF domain (244 - 454)

RA

RA: Ras association (RalGDS/AF-6) domain (615 - 699)

  • 0
  • 200
  • 400
  • 600
  • 710 a.a.
Protein Preferred Names Protein Names

ral guanine nucleotide dissociation stimulator-like 3

RalGEF-like protein 3, mouse homolog

RGL3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RGL3 Q3MIN7 FAM200A Homo sapiens Q8TCP9
Validated Y2H
32296183
Intra
RGL3 Q3MIN7 FAM200A Homo sapiens Q8TCP9
Y2H Array
32296183
Intra
RGL3 Q3MIN7 FAM200A Homo sapiens Q8TCP9
Y2H Prey Pooling
32296183
Intra
RGL3 Q3MIN7 RIT1 Homo sapiens Q92963
Y2H Prey Pooling
32296183
Intra
RGL3 Q3MIN7 RIT1 Homo sapiens Q92963
Validated Y2H
32296183
Intra
RGL3 Q3MIN7 RIT1 Homo sapiens Q92963
Y2H Array
32296183
Intra
RGL3 Q3MIN7 RIT2 Homo sapiens Q99578
Y2H Prey Pooling
32296183
Intra
RGL3 Q3MIN7 RIT2 Homo sapiens Q99578
Validated Y2H
32296183
Intra
RGL3 Q3MIN7 RIT2 Homo sapiens Q99578
Y2H Array
32296183
Intra
RGL3 Q3MIN7 RRAS2 Homo sapiens P62070
Y2H Prey Pooling
32296183
Intra
RGL3 Q3MIN7 RRAS2 Homo sapiens P62070
Y2H Array
32296183
Intra
RGL3 Q3MIN7 NRAS Homo sapiens P01111
Y2H Array
32296183
Intra
RGL3 Q3MIN7 NRAS Homo sapiens P01111
Y2H Prey Pooling
32296183
Intra
RGL3 Q3MIN7 KLHL12 Homo sapiens Q53G59
Y2H Array
32296183
Intra
RGL3 Q3MIN7 KLHL12 Homo sapiens Q53G59
Y2H Prey Pooling
32296183
Intra
RGL3 Q3MIN7 KLHL12 Homo sapiens Q53G59
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11892 RGL3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RGL3 VGNC VGNC:33905
Felis catus RGL3 VGNC VGNC:64591
Rattus norvegicus RGL3 RGD RGD:1309756
Canis familiaris RGL3 VGNC VGNC:45514
Macaca mulatta RGL3 VGNC VGNC:76869
Mus musculus RGL3 MGD MGI:1918996
Others RGL3 NCBI