1. Gene
  2. SCYL3 - SCY1 like pseudokinase 3 Gene

SCYL3 - SCY1 like pseudokinase 3 Gene

Homo sapiens

Also known as PACE1; PACE-1

Gene ID: 57147 | Gene type: protein coding

About SCYL3

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:169,849,631-169,894,268 (from NCBI)

This gene has 5 transcripts (splice variants), 201 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 4.6), testis (RPKM 4.3) and 25 other tissues.

Summary

This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]

SCYL3 Products(2)

mRNA Protein Name
NM_020423.7 NP_065156.5 protein-associating with the carboxyl-terminal domain of ezrin isoform 1
NM_181093.4 NP_851607.2 protein-associating with the carboxyl-terminal domain of ezrin isoform 2
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
NOT enables kinase activity IDA
IDA: Inferred from direct assay
12651155 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12651155 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
12651155 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
12651155 GOA
located in lamellipodium IDA
IDA: Inferred from direct assay
12651155 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCYL3 Protein Structure

Pkinase

Pkinase: Protein kinase domain (36 - 236)

  • 0
  • 200
  • 400
  • 600
  • 742 a.a.
Protein Preferred Names Protein Names

protein-associating with the carboxyl-terminal domain of ezrin

SCY1-like 3

SCYL3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SCYL3 Q8IZE3 EZR Homo sapiens P15311 12651155
Intra
SCYL3 Q8IZE3 EZR Homo sapiens P15311
Y2H
12651155
Intra
SCYL3 Q8IZE3 EZR Homo sapiens P15311 32707033
Intra
SCYL3 Q8IZE3 TXN2 Homo sapiens Q99757 25416956
Intra
SCYL3 Q8IZE3 TXN2 Homo sapiens Q99757 25416956
Intra
SCYL3 Q8IZE3 TXN2 Homo sapiens Q99757 25416956
Intra
SCYL3 Q8IZE3 GABARAPL1 Homo sapiens Q9H0R8 25416956
Intra
SCYL3 Q8IZE3 GABARAPL1 Homo sapiens Q9H0R8 25416956
Intra
SCYL3 Q8IZE3 GABARAPL1 Homo sapiens Q9H0R8 25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Afferent Loop Syndrome

Afferent Limb Syndrome

Facial Neuralgia
Herpes Zoster Oticus

Nervus Intermedius Neuralgia

Ramsay Hunt Syndrome Type 2

Geniculate Herpes Zoster

Geniculate Neuralgia

Herpes Zoster Auricularis

Herpetic Geniculate Ganglionitis

Ramsay Hunt Syndrome Type Ii

Ramsey Hunt Syndrome

Facial Nerve Palsy Due To Vzv

Facial Nerve Palsy Due To Herpes Zoster Infection

Facial Nerve Paralysis Due To Vzv

Hunt Syndrome

Hunt'S Syndrome

Ramsay Hunt Syndrome

Myoclonus And Ataxia

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus SCYL3 MGD MGI:1921385
Rattus norvegicus SCYL3 RGD RGD:1308992
Canis familiaris SCYL3 VGNC VGNC:45940
Bos taurus SCYL3 VGNC VGNC:34376
Macaca mulatta SCYL3 VGNC VGNC:77053
Felis catus SCYL3 VGNC VGNC:64942
Others SCYL3 NCBI