SCYL3 - SCY1 like pseudokinase 3 Gene

Homo sapiens

Also known as PACE1; PACE-1

Gene ID: 57147 | Gene type: protein coding

About SCYL3

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:169,849,631-169,894,268 (from NCBI)

This gene has 5 transcripts (splice variants), 201 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 4.6), testis (RPKM 4.3) and 25 other tissues.

Summary

This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]

SCYL3 Products(2)

mRNA	Protein	Name
NM_020423.7	NP_065156.5	protein-associating with the carboxyl-terminal domain of ezrin isoform 1
NM_181093.4	NP_851607.2	protein-associating with the carboxyl-terminal domain of ezrin isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables kinase activity	IDA IDA: Inferred from direct assay	12651155	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12651155	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	12651155	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12651155	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	12651155	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCYL3 Protein Structure

Pkinase

0
200
400
600
742 a.a.

Protein Preferred Names

Protein Names

protein-associating with the carboxyl-terminal domain of ezrin

SCY1-like 3

SCYL3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SCYL3	Q8IZE3	EZR	Homo sapiens	P15311	Confocal	12651155
Intra	SCYL3	Q8IZE3	EZR	Homo sapiens	P15311	Y2H	12651155
Intra	SCYL3	Q8IZE3	EZR	Homo sapiens	P15311	Pull Down	32707033
Intra	SCYL3	Q8IZE3	TXN2	Homo sapiens	Q99757	Y2H Prey Pooling	25416956
Intra	SCYL3	Q8IZE3	TXN2	Homo sapiens	Q99757	Validated Y2H	25416956
Intra	SCYL3	Q8IZE3	TXN2	Homo sapiens	Q99757	Y2H Array	25416956
Intra	SCYL3	Q8IZE3	GABARAPL1	Homo sapiens	Q9H0R8	Validated Y2H	25416956
Intra	SCYL3	Q8IZE3	GABARAPL1	Homo sapiens	Q9H0R8	Y2H Array	25416956
Intra	SCYL3	Q8IZE3	GABARAPL1	Homo sapiens	Q9H0R8	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Afferent Loop Syndrome

Afferent Limb Syndrome

Facial Neuralgia

Herpes Zoster Oticus

Nervus Intermedius Neuralgia	Ramsay Hunt Syndrome Type 2
Geniculate Herpes Zoster	Geniculate Neuralgia
Herpes Zoster Auricularis	Herpetic Geniculate Ganglionitis
Ramsay Hunt Syndrome Type Ii	Ramsey Hunt Syndrome
Facial Nerve Palsy Due To Vzv	Facial Nerve Palsy Due To Herpes Zoster Infection
Facial Nerve Paralysis Due To Vzv	Hunt Syndrome
Hunt'S Syndrome	Ramsay Hunt Syndrome
Myoclonus And Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12577	SCYL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SCYL3	MGD	MGI:1921385
Rattus norvegicus	SCYL3	RGD	RGD:1308992
Canis familiaris	SCYL3	VGNC	VGNC:45940
Bos taurus	SCYL3	VGNC	VGNC:34376
Macaca mulatta	SCYL3	VGNC	VGNC:77053
Felis catus	SCYL3	VGNC	VGNC:64942
Others	SCYL3	NCBI

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