2. Gene
  3. PSMD10 - proteasome 26S subunit, non-ATPase 10 Gene

PSMD10 - proteasome 26S subunit, non-ATPase 10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as p28; p28(GANK); dJ889N15.2

Gene ID: 5716 | Gene type: protein coding

About PSMD10

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:108,084,207-108,091,542 (from NCBI)

This gene has 7 transcripts (splice variants), 225 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 23.6), thyroid (RPKM 20.0) and 25 other tissues.

Summary

This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S Proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011]

PSMD10 Products(2)

mRNA Protein Name
NM_002814.4 NP_002805.1 26S proteasome non-ATPase regulatory subunit 10 isoform 1
NM_170750.3 NP_736606.1 26S proteasome non-ATPase regulatory subunit 10 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10613832 GOA
enables transcription factor binding IPI
IPI: Inferred from physical interaction
18040287 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cytoplasmic sequestering of NF-kappaB IDA
IDA: Inferred from direct assay
18040287 GOA
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
IDA: Inferred from direct assay
16023600 GOA
involved in negative regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
19729910 GOA
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
18040287 GOA
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
16023600 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
19729910 GOA
involved in negative regulation of release of cytochrome c from mitochondria IMP
IMP: Inferred from mutant phenotype
19729910 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16023600 GOA
involved in positive regulation of cell growth IDA
IDA: Inferred from direct assay
10613832 GOA
involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
11900540 GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
16023600 GOA
involved in positive regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
16023600 GOA
involved in proteasome regulatory particle assembly IMP
IMP: Inferred from mutant phenotype
19490896 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18040287 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18040287 GOA
part of proteasome complex IDA
IDA: Inferred from direct assay
17323924 GOA
part of proteasome regulatory particle, base subcomplex IDA
IDA: Inferred from direct assay
19490896 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMD10 Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (34 - 103)

Ank

Ank: Ankyrin repeat (105 - 136)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (139 - 201)

  • 0
  • 100
  • 200
  • 226 a.a.
Protein Preferred Names Protein Names

26S proteasome non-ATPase regulatory subunit 10

26S proteasome regulatory subunit p28

PSMD10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PSMD10 O75832 GRSF1 Homo sapiens Q12849
Anti Bait CoIP
24338975
Intra
PSMD10 O75832 GRSF1 Homo sapiens Q12849
Anti Tag CoIP
24338975
Intra
PSMD10 O75832 HSPA1A Homo sapiens P0DMV8
Pull Down
24338975
Intra
PSMD10 O75832 CLIC1 Homo sapiens O00299
Pull Down
24338975
Intra
PSMD10 O75832 CLIC1 Homo sapiens O00299
Anti Tag CoIP
24338975
Intra
PSMD10 O75832 CLIC1 Homo sapiens O00299
Anti Bait CoIP
24338975
Intra
PSMD10 O75832 MAGEA4 Homo sapiens P43358
Anti Bait CoIP
12525503
Intra
PSMD10 O75832 MAGEA4 Homo sapiens P43358
Y2H
12525503
Intra
PSMD10 O75832 MAGEA4 Homo sapiens P43358
Anti Tag CoIP
12525503
Intra
PSMD10 O75832 PSMC4 Homo sapiens P43686
Anti Tag CoIP
19490896
Intra
PSMD10 O75832 PSMC4 Homo sapiens P43686
Y2H
21988832
Intra
PSMD10 O75832 PSMC4 Homo sapiens P43686
Anti Bait CoIP
17353931
Intra
PSMD10 O75832 PSMC4 Homo sapiens P43686
Complementation
32296183
Intra
PSMD10 O75832 PSMC4 Homo sapiens P43686
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PSMD10 Proteins

Cat. No. Product Name Accession Purity
HY-P70213 Gankyrin/PSMD10 Protein, Human O75832-1 (M1-G226) ≥95%

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms
Uterine Corpus Sarcoma

Sarcoma Of Corpus Uteri

Sarcoma Of Uterus

Sarcoma Of The Corpus Uteri

Uterine Sarcoma

Sarcoma, Nos Of Uterus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11318 PSMD10 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PSMD10 VGNC VGNC:97572
Canis familiaris PSMD10 VGNC VGNC:45106
Macaca mulatta PSMD10 VGNC VGNC:103851
Mus musculus PSMD10 MGD MGI:1858898
Rattus norvegicus PSMD10 RGD RGD:620350
Others PSMD10 NCBI