THOC2 - THO complex subunit 2 Gene

Homo sapiens

Also known as THO2; MRX12; MRX35; CXorf3; XLID12; hTREX120; dJ506G2.1

Gene ID: 57187 | Gene type: protein coding

About THOC2

Cytogenetic location: Xq25 Genomic coordinates (GRCh38): X:123,600,569-123,733,052 (from NCBI)

This gene has 20 transcripts (splice variants), 231 orthologues and is associated with 3 phenotypes. Ubiquitous expression in lymph node (RPKM 8.1), thyroid (RPKM 7.3) and 25 other tissues.

Summary

The TREX multiprotein complex binds specifically to spliced mRNAs to facilitate mRNA export. The protein encoded by this gene is a member of the THO complex, a subset of the TREX complex. The encoded protein interacts with the THOC1 protein.[provided by RefSeq, Jun 2010]

THOC2 Products(1)

mRNA	Protein	Name
NM_001081550.2	NP_001075019.1	THO complex subunit 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15870275	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in generation of neurons	IMP IMP: Inferred from mutant phenotype	26166480	GOA
involved in mRNA export from nucleus	IDA IDA: Inferred from direct assay	17190602	GOA
involved in neuron development	IMP IMP: Inferred from mutant phenotype	26166480	GOA
involved in poly(A)+ mRNA export from nucleus	IDA IDA: Inferred from direct assay	22928037	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of THO complex	IDA IDA: Inferred from direct assay	15998806	GOA
part of THO complex part of transcription export complex	IDA IDA: Inferred from direct assay	15998806	GOA
colocalizes with chromosome, telomeric region	IDA IDA: Inferred from direct assay	24270157	GOA
part of transcription export complex	IDA IDA: Inferred from direct assay	15833825	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THOC2 Protein Structure

Thoc2

Tho2

0
300
600
900
1200
1500
1593 a.a.

Protein Preferred Names

Protein Names

THO complex subunit 2

THO complex 2

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, X-Linked 12

XLID12	Mrx12
Mental Retardation, X-Linked 35	Mrx35
Mental Retardation, X-Linked 12

X-Linked Intellectual Disability-Short Stature-Overweight Syndrome

Mrx12	Mrx35
X-Linked Mental Retardation 12	X-Linked Mental Retardation 35

Anterior Horn Cell Disease

Lethal Congenital Contracture Syndrome 1

LCCS1	Multiple Contracture Syndrome, Finnish Type
Lccs	Lethal Autosomal Recessive Syndrome Of Multiple Congenital Contractures
Lethal Congenital Contracture Syndrome Type 1	Herva Disease
Multiple Contracture Syndrome Finnish Type	Contracture Syndrome, Lethal, Congenital, Type 1

Spinal Muscular Atrophy, Type I

Werdnig-Hoffmann Disease	SMA1
Spinal Muscular Atrophy 1	Sma I
Sma, Infantile Acute Form	Muscular Atrophy, Infantile
Spinal Muscular Atrophy-1	Hmn Proximal Type I
Infantile Muscular Atrophy	Proximal Spinal Muscular Atrophy Type 1
Sma Type 1	Sma Type I
Sma-I	Hereditary Motor Neuropathy Proximal Type I
Progressive Muscular Atrophy Of Infancy	Proximal Spinal Muscular Atrophy, Type 1
Werdnig Hoffmann Disease	Infantile Spinal Muscular Atrophy
Infantile-Onset Spinal Muscular Atrophy	Proximal Hereditary Motor Neuropathy Type I
Sma Infantile Acute Form	Spinal Muscular Atrophy Type I
Werdnig-Hoffman Disease	Atrophy, Muscular, Spinal, Type 1

Lethal Congenital Contracture Syndrome

Lccs	Lethal Congenital Contracture Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14492	THOC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	THOC2	VGNC	VGNC:66167
Rattus norvegicus	THOC2	RGD	RGD:1561623
Canis familiaris	THOC2	VGNC	VGNC:47349
Mus musculus	THOC2	MGD	MGI:2442413
Macaca mulatta	THOC2	VGNC	VGNC:79177

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