RCN3 - reticulocalbin 3 Gene

Homo sapiens

Also known as RLP49

Gene ID: 57333 | Gene type: protein coding

About RCN3

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,528,003-49,543,633 (from NCBI)

This gene has 5 transcripts (splice variants), 105 orthologues and 4 paralogues. Ubiquitous expression in fat (RPKM 12.8), placenta (RPKM 11.9) and 24 other tissues.

Summary

Enables calcium ion binding activity. Involved in several processes, including collagen biosynthetic process; positive regulation of peptidase activity; and regulation of protein kinase B signaling. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

RCN3 Products(1)

mRNA	Protein	Name
NM_020650.3	NP_065701.2	reticulocalbin-3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	16433634	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	28939891	GOA
involved in positive regulation of peptidase activity	IMP IMP: Inferred from mutant phenotype	28939891	GOA
involved in protein secretion	IMP IMP: Inferred from mutant phenotype	16433634	GOA
involved in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	28939891	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16433634	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RCN3 Protein Structure

EF-hand_7

EF-hand_5

EF-hand_8

0
100
200
300
328 a.a.

Protein Preferred Names

Protein Names

reticulocalbin-3

EF-hand calcium-binding protein RLP49

RCN3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RCN3	Q96D15	PACRGL	Homo sapiens	Q8N7B6	Y2H Array	25416956
Intra	RCN3	Q96D15	PACRGL	Homo sapiens	Q8N7B6	Y2H Prey Pooling	25416956
Intra	RCN3	Q96D15	SUFU	Homo sapiens	Q9UMX1	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RCN3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71253	RCN3 Protein, Human (HEK293, His)	Q96D15 (K21-L328)	≥95%

Related Diseases

Diseases

Alias

Myopathy, Distal, 3

MPD3	Distal Muscular Dystrophy 3
Distal Myopathy Type 3	Myopathy, Distal 3
Distal Myopathy 3	Finnish Upper Limb-Onset Distal Myopathy

Neonatal Respiratory Failure

Respiratory Failure Of Newborn	Inadequate Pulmonary Ventilation Of Newborn
Newborn Lung Insufficiency	Newborn Pulmonary Function Inadequate
Newborn Pulmonary Insufficiency	Newborn Respiration Failure
Newborn Respiratory Insufficiency	Respiratory Insufficiency Syndrome Of Newborn

Enchondromatosis, Multiple, Ollier Type

Ollier Disease	Enchondromatosis
Dyschondroplasia	Osteochondromatosis
Multiple Cartilaginous Enchondroses	Multiple Enchondromatosis
Enchondromatosis With Haemangiomata	Enchondromatosis, Multiple
Kast'S Syndrome	Ollier'S Syndrome
Enchondromatosis Multiple	ENCHOM
Maffucci Disease	Olliers Disease
Hereditary Multiple Exostoses	Chondromatosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11790	RCN3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RCN3	VGNC	VGNC:33833
Canis familiaris	RCN3	VGNC	VGNC:45445
Mus musculus	RCN3	MGD	MGI:1277122
Rattus norvegicus	RCN3	RGD	RGD:1359365
Others	RCN3	NCBI

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