PTGER4 - prostaglandin E receptor 4 Gene

Homo sapiens

Also known as EP4; EP4R

Gene ID: 5734 | Gene type: protein coding

About PTGER4

Cytogenetic location: 5p13.1 Genomic coordinates (GRCh38): 5:40,679,915-40,746,800 (from NCBI)

This gene has 5 transcripts (splice variants), 275 orthologues and 7 paralogues. Broad expression in bone marrow (RPKM 30.5), colon (RPKM 12.1) and 18 other tissues.

Summary

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]

PTGER4 Products(1)

mRNA	Protein	Name
NM_000958.3	NP_000949.1	prostaglandin E2 receptor EP4 subtype

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables prostaglandin E receptor activity	IDA IDA: Inferred from direct assay	8078484	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16424369	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	8078484	GOA
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	16204467	GOA
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	8163486	GOA
involved in immune response	IEP IEP: Inferred from expression pattern	8862514	GOA
involved in negative regulation of eosinophil extravasation	IDA IDA: Inferred from direct assay	21681739	GOA
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	16424369	GOA
involved in negative regulation of integrin activation	IDA IDA: Inferred from direct assay	21681739	GOA
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	21723865	GOA
involved in response to prostaglandin E	IDA IDA: Inferred from direct assay	8163486	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	8163486	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTGER4 Protein Structure

7tm_1

0
100
200
300
400
488 a.a.

Protein Preferred Names

Protein Names

prostaglandin E2 receptor EP4 subtype

PGE receptor, EP4 subtype

Related Diseases

Diseases

Alias

Basosquamous Carcinoma

Carcinoma, Basosquamous	Basisquamous Cell Carcinoma
Basosquamous Cell Carcinoma	Metatypical Carcinoma

Vulvar Sebaceous Carcinoma

Malignant Epithelial Mesothelioma

Epithelioid Mesothelioma, Malignant

Vulva Basal Cell Carcinoma

Basal Cell Carcinoma Of Vulva

Basal Cell Carcinoma Of The Vulva

Epididymis Adenocarcinoma

Adenocarcinoma Of The Epididymis

Epididymis Cancer

Malignant Tumor Of Epididymis	Malignant Epididymal Tumor
Malignant Neoplasm Of Epididymis	Neoplasm Of Epididymis

Metatypical Basal Cell Carcinoma

Skin Metatypical Carcinoma	Basosquamous Carcinoma Of Skin
Skin Metatypical Basal Cell Carcinoma

Papillary Thymic Adenocarcinoma

Papillary Carcinoma Of The Thymus

Fallopian Tube Serous Adenocarcinoma

Peritoneal Serous Papillary Adenocarcinoma

Primary Serous Papillary Carcinoma Of Peritoneum

Vulvar Eccrine Porocarcinoma

Lymphohistiocytoid Mesothelioma

Malignant Syringoma

Microcystic Adnexal Carcinoma	Microcystic Adnexal Carcinoma Of Skin
Syringomatous Carcinoma	Eccrine Epithelioma

Skin Amelanotic Melanoma

Skin Amelanotic Malignant Melanoma

Amelanotic Skin Melanoma

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Rete Testis Neoplasm

Rete Testis Adenocarcinoma

Adenocarcinoma Of Rete Testis

Adenocarcinoma Of The Rete Testis

Large Cell Acanthoma

Anus Basaloid Carcinoma

Basaloid Carcinoma Of The Anus

Anal Basaloid Carcinoma

Sarcomatoid Basal Cell Carcinoma

Skin Sarcomatoid Basal Cell Carcinoma

Inverted Follicular Keratosis

Inverted Folicular Keratosis

Seborrheic Keratosis

Peritoneal Serous Adenocarcinoma

Primary Peritoneal Serous Adenocarcinoma

Nodular Hidradenoma

Eccrine Nodular Hidradenoma

Eccrine Acrospiroma

Bartholin'S Gland Adenocarcinoma

Bartholin Gland Adenocarcinoma	Adenocarcinoma Of Bartholin'S Gland
Adenocarcinoma Of The Bartholin'S Gland

Pigmented Basal Cell Carcinoma

Skin Pigmented Basal Cell Carcinoma

Peritoneal Mesothelioma

Malignant Mesothelioma Of Peritoneum	Advanced Malignant Mesothelioma Of Peritoneum
Advanced Malignant Peritoneal Mesothelioma	Advanced Peritoneal Malignant Mesothelioma

Sarcomatoid Mesothelioma

Malignant Fibrous Mesothelioma

Spindled Mesothelioma

Penis Basal Cell Carcinoma

Basal Cell Carcinoma Of The Penis

Eccrine Sweat Gland Cancer

Malignant Eccrine Skin Neoplasm

Malignant Eccrine Tumor

Endosalpingiosis

Pericardial Mesothelioma

Malignant Mesothelioma Of Pericardium

Malignant Pericardial Mesothelioma

Peritoneum Cancer

Peritoneal Neoplasm	Cancer Of Peritoneum
Malignant Tumor Of Peritoneum	Peritoneal Neoplasms

Pericardium Cancer

Malignant Neoplasm Of Pericardium	Malignant Tumor Of Pericardium
Pericardial Tumor	Neoplasm Of Pericardium

Primary Hypertrophic Osteoarthropathy

Pachydermoperiostosis Syndrome	Osteoarthropathy, Primary Hypertrophic
Pachydermoperiostosis Of Nail	Idiopathic Hypertrophic Osteoarthropathy
Pho

Basaloid Squamous Cell Carcinoma

Basaloid Carcinoma

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Benign Peritoneal Mesothelioma

Mesothelioma Of Peritoneum

Benign Neoplasm Of Mesothelial Tissue Of Peritoneum

Patent Ductus Arteriosus 1

Patent Ductus Arteriosus	PDA1
Pda	Ductus Arteriosus, Patent
Patent Ductus Arteriosus, Susceptibility To	Patent Ductus Botalli
Patency Of The Ductus Arteriosus	Patent Ductus Arteriosus Familial
Ductus Arteriosus Patent	Patent Ductus Arteriosus - Persisting Type

Comedo Carcinoma

Comedocarcinoma

High Grade Ductal Breast Carcinoma In Situ

Papillary Serous Adenocarcinoma

Micropapillary Serous Carcinoma	Serous Surface Papillary Carcinoma
Papillary Serous Carcinoma	Papillary Serous Cystadenocarcinoma

Squamous Papillomatosis

Borst-Jadassohn Intraepidermal Carcinoma

Intraepidermal Epithelioma Of Jadassohn

Bowen'S Disease, Clonal

Cystic Basal Cell Carcinoma

Skin Cystic Basal Cell Carcinoma

Muir-Torre Syndrome

MRTES	Keratoacanthoma
Muir-Torré Syndrome	Cutaneous Sebaceous Neoplasms And Keratoacanthomas, Multiple, With Gastrointestinal And Other Carcinomas
Cutaneous Sebaceous Neoplasms And Keratoacanthomas Multiple With Gastrointestinal And Other Carcinomas	Multiple Keratoacanthoma, Muir-Torre Type
Mts	Torre-Muir Syndrome

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Mesothelioma, Malignant

Malignant Mesothelioma	Pleural Mesothelioma
MESOM	Mesothelioma, Somatic
Advanced Malignant Mesothelioma	Asbestos-Related Malignant Mesothelioma
Diffuse Malignant Mesothelioma	Malignant Tumor Of Mesothelium
Malignant Mesothelioma, Susceptibility To	Mesothelioma Diffuse Malignant
Mesothelioma	Malignant Pleural Mesothelioma

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Basal Cell Carcinoma

Basal Cell Cancer	Basal Cell Neoplasm
Basal Cell Carcinoma Of Skin	Malignant Basal Cell Tumor
Basal Cell Tumor	Epithelioma Basal Cell
Malignant Basal Cell Neoplasm	Rodent Ulcer
Carcinoma Basal Cell	Neoplasms, Basal Cell
Basal Cell Carcinomas	Experimental Organism Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Basalioma
Basal Cell Epithelioma Of Skin	Bcc - [Basal Cell Carcinoma] Of Skin
Rodent Ulcer Of Skin	Rodent Ulcer Of Unspecified Site
Basal Cell Epithelioma Of Unspecified Site

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS11378	PTGER4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PTGER4	VGNC	VGNC:45144
Macaca mulatta	PTGER4	VGNC	VGNC:76470
Rattus norvegicus	PTGER4	RGD	RGD:628641
Bos taurus	PTGER4	VGNC	VGNC:33504
Mus musculus	PTGER4	MGD	MGI:104311