PTGIS - prostaglandin I2 synthase Gene

Homo sapiens

Also known as CYP8; PGIS; PTGI; CYP8A1

Gene ID: 5740 | Gene type: protein coding

About PTGIS

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:49,503,874-49,568,137 (from NCBI)

This gene has 2 transcripts (splice variants), 250 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in urinary bladder (RPKM 26.9), gall bladder (RPKM 23.0) and 16 other tissues.

Summary

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and other lipids. However, this protein is considered a member of the Cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]

PTGIS Products(1)

mRNA	Protein	Name
NM_000961.4	NP_000952.1	prostacyclin synthase precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables heme binding	IDA IDA: Inferred from direct assay	17020766	GOA
enables prostaglandin-I synthase activity	IDA IDA: Inferred from direct assay	15115769	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20122998	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	11551955	GOA
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	21296955	GOA
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	8185632	GOA
involved in cellular response to interleukin-6	IEP IEP: Inferred from expression pattern	8185632	GOA
involved in icosanoid metabolic process	IDA IDA: Inferred from direct assay	15115769	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	20159982	GOA
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	20159982	GOA
involved in negative regulation of nitric oxide biosynthetic process	IDA IDA: Inferred from direct assay	20159982	GOA
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	20122998	GOA
involved in positive regulation of execution phase of apoptosis	IDA IDA: Inferred from direct assay	11551955	GOA
involved in positive regulation of peroxisome proliferator activated receptor signaling pathway	IDA IDA: Inferred from direct assay	11551955	GOA
involved in prostaglandin biosynthetic process	IDA IDA: Inferred from direct assay	15115769	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in caveola	IDA IDA: Inferred from direct assay	20122998	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21035466	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21035466	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTGIS Protein Structure

p450

0
100
200
300
400
500 a.a.

Protein Preferred Names

Protein Names

prostacyclin synthase

cytochrome P450, family 8, subfamily A, polypeptide 1

Related Diseases

Diseases

Alias

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Childhood-Onset Schizophrenia

Childhood Schizophrenia

Schizophrenia, Childhood

Pulmonary Hypertension

Primary Pulmonary Hypertension	Hypertension Pulmonary
Hypertension, Pulmonary	Hypertension, Pulmonary, Primary
Idiopathic Pulmonary Hypertension	Idiopathic Pulmonary Arterial Hypertension
Pulmonary Htn - [Hypertension]

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Lung Benign Neoplasm

Lung Neoplasms	Tumor Of The Lung
Lung Tumor

Acute Stress Disorder

Traumatic Stress Disorder	Stress Disorders, Traumatic, Acute
Stress Disorders, Traumatic

Trichothiodystrophy

Ttd	Amish Brittle Hair Syndrome
Bids Syndrome	Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome
Ibids	Pibids
Trichothiodystrophy Syndromes

Post-Traumatic Stress Disorder

PTSD	Traumatic Neurosis
Post Traumatic Stress Disorder	Stress Disorders, Post-Traumatic
Posttraumatic Stress Disorder	Ptsd - [Post Traumatic Stress Disorder]
Trauma-Related Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11389	PTGIS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PTGIS	RGD	RGD:3438
Macaca mulatta	PTGIS	VGNC	VGNC:76587
Mus musculus	PTGIS	MGD	MGI:1097156
Canis familiaris	PTGIS	VGNC	VGNC:45149
Bos taurus	PTGIS	VGNC	VGNC:33509
Felis catus	PTGIS	VGNC	VGNC:69146

Name
Email *

	Sorry, but the email address you supplied was invalid.