S100A14 - S100 calcium binding protein A14 Gene

Homo sapiens

Also known as BCMP84; S100A15

Gene ID: 57402 | Gene type: protein coding

About S100A14

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,614,255-153,616,325 (from NCBI)

This gene has 6 transcripts (splice variants), 355 orthologues and 21 paralogues. Biased expression in esophagus (RPKM 798.1), skin (RPKM 171.2) and 6 other tissues.

Summary

This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828). [provided by RefSeq, Dec 2011]

S100A14 Products(1)

mRNA	Protein	Name
NM_020672.3	NP_065723.1	protein S100-A14

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chemokine receptor binding	IMP IMP: Inferred from mutant phenotype	18606705	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in defense response to bacterium	IEP IEP: Inferred from expression pattern	17625598	GOA
involved in positive regulation of granulocyte chemotaxis	IDA IDA: Inferred from direct assay	18606705	GOA
involved in positive regulation of monocyte chemotaxis	IDA IDA: Inferred from direct assay	18606705	GOA
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	17625598	GOA
involved in toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	17625598	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11944983	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S100A14 Protein Structure

S_100

0
104 a.a.

Protein Preferred Names

Protein Names

protein S100-A14

S114

S100A14 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	S100A14	Q9HCY8	MAGEA6	Homo sapiens	P43360	Validated Y2H	25416956
Intra	S100A14	Q9HCY8	MAGEA6	Homo sapiens	P43360	Y2H Array	25416956
Intra	S100A14	Q9HCY8	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	25416956
Intra	S100A14	Q9HCY8	S100A16	Homo sapiens	Q96FQ6	Validated Y2H	25416956
Intra	S100A14	Q9HCY8	S100A16	Homo sapiens	Q96FQ6	Y2H Prey Pooling	25416956
Intra	S100A14	Q9HCY8	S100A16	Homo sapiens	Q96FQ6	Y2H Array	25416956
Intra	S100A14	Q9HCY8	S100A16	Homo sapiens	Q96FQ6	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant S100A14 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76584	S100A14 Protein, Human (His)	Q9HCY8.1 (G2-H104)	≥95%

Related Diseases

Diseases

Alias

Trachea Leiomyoma

Tracheal Neoplasms	Leiomyoma Of The Trachea
Tracheal Neoplasm	Tracheal Leiomyoma

Small Intestine Adenocarcinoma

Small Intestinal Adenocarcinoma	Adenocarcinoma Of Small Intestine
Adenocarcinoma Of The Small Bowel	Adenocarcinoma Of Small Bowel
Adenocarcinoma Of Small Instestine	Adenocarcinoma Of The Small Instestine
Small Bowel Adenocarcinoma	Adenocarcinoma Of The Small Intestine

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12376	S100A14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	S100A14	VGNC	VGNC:34240
Mus musculus	S100A14	MGD	MGI:1913416
Canis familiaris	S100A14	VGNC	VGNC:45826
Felis catus	S100A14	VGNC	VGNC:64839
Rattus norvegicus	S100A14	RGD	RGD:1595063
Others	S100A14	NCBI

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