MRTFB - myocardin related transcription factor B Gene

Homo sapiens

Also known as MKL2; MRTF-B; NPD001

Gene ID: 57496 | Gene type: protein coding

About MRTFB

Cytogenetic location: 16p13.12 Genomic coordinates (GRCh38): 16:13,994,774-14,266,779 (from NCBI)

This gene has 13 transcripts (splice variants), 278 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 11.0), testis (RPKM 5.1) and 24 other tissues.

Summary

Enables transcription coactivator activity. Involved in positive regulation of pri-miRNA transcription by RNA polymerase II and positive regulation of striated muscle tissue development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

MRTFB Products(13)

mRNA	Protein	Name
NM_001308142.2	NP_001295071.1	myocardin-related transcription factor B isoform 1
NM_001365411.2	NP_001352340.1	myocardin-related transcription factor B isoform 3
NM_001365412.2	NP_001352341.1	myocardin-related transcription factor B isoform 4
NM_001365413.2	NP_001352342.1	myocardin-related transcription factor B isoform 5
NM_001365414.2	NP_001352343.1	myocardin-related transcription factor B isoform 6
NM_001365415.2	NP_001352344.1	myocardin-related transcription factor B isoform 7
NM_001365416.2	NP_001352345.1	myocardin-related transcription factor B isoform 8
NM_001365417.3	NP_001352346.1	myocardin-related transcription factor B isoform 9
NM_001365418.3	NP_001352347.1	myocardin-related transcription factor B isoform 9
NM_001365419.3	NP_001352348.1	myocardin-related transcription factor B isoform 9
NM_001365420.3	NP_001352349.1	myocardin-related transcription factor B isoform 9
NM_001365421.3	NP_001352350.1	myocardin-related transcription factor B isoform 9
NM_014048.4	NP_054767.3	myocardin-related transcription factor B isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12397177	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	14565952	GOA
enables transcription coactivator activity	IGI IGI: Inferred from genetic interaction	23764775	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of miRNA transcription	IGI IGI: Inferred from genetic interaction	23764775	GOA
involved in positive regulation of striated muscle tissue development	IDA IDA: Inferred from direct assay	14565952	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14565952	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRTFB Protein Structure

RPEL

SAP

0
200
400
600
800
1049 a.a.

Protein Preferred Names

Protein Names

myocardin-related transcription factor B

CTA-276F8.1

MRTFB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MRTFB	Q9ULH7	SRF	Homo sapiens	P11831	Affinity Techniques	14565952

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chondroid Lipoma

Spondylometaphyseal Dysplasia, Sedaghatian Type

SMDS	Sedaghatian Chondrodysplasia
Spondylometaphyseal Dysplasia Sedaghatian Type	Congenital Lethal Metaphyseal Chondrodysplasia
Metaphyseal Chondrodysplasia, Congenital Lethal	Lethal Metaphyseal Dysplasia

Schizophrenia 12

Sczd12

Schizophrenia Susceptibility Locus, Chromosome 1p-Related

Left Ventricular Noncompaction

Noncompaction Cardiomyopathy	Left Ventricular Hypertrabeculation
Lvnc	Spongy Myocardium
Isolated Noncompaction Of The Ventricular Myocardium	Left Ventricular Myocardial Noncompaction Cardiomyopathy
Fetal Myocardium	Honeycomb Myocardium
Hypertrabeculation Syndrome	Left Ventricular Non-Compaction
Lvht	Non-Compaction Of The Left Ventricular Myocardium
Ventricular Noncompaction, Left	Non-Compaction Cardiomyopathy

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08694	MRTFB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MRTFB	VGNC	VGNC:31489
Felis catus	MRTFB	VGNC	VGNC:63628
Canis familiaris	MRTFB	VGNC	VGNC:43249
Mus musculus	MRTFB	MGD	MGI:3050795
Rattus norvegicus	MRTFB	RGD	RGD:1560833
Macaca mulatta	MRTFB	VGNC	VGNC:74865

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