SRF - serum response factor Gene

Homo sapiens

Also known as MCM1

Gene ID: 6722 | Gene type: protein coding

About SRF

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:43,171,269-43,181,506 (from NCBI)

This gene has 1 transcript (splice variant), 279 orthologues and 4 paralogues. Ubiquitous expression in prostate (RPKM 20.2), heart (RPKM 19.8) and 25 other tissues.

Summary

This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-Fos, and thereby participates in cell cycle regulation, Apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

SRF Products(2)

mRNA	Protein	Name
NM_001292001.2	NP_001278930.1	serum response factor isoform 2
NM_003131.4	NP_003122.1	serum response factor isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20808827	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IGI IGI: Inferred from genetic interaction	23764775	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	3203386	GOA
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	18296735	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	16054032	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1509260	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7854423	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	3203386	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables serum response element binding	IDA IDA: Inferred from direct assay	3203386	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cardiac muscle cell myoblast differentiation	IGI IGI: Inferred from genetic interaction	19783823	GOA
involved in cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	15180964	GOA
involved in cellular senescence	IMP IMP: Inferred from mutant phenotype	15282327	GOA
involved in negative regulation of amyloid-beta clearance	IMP IMP: Inferred from mutant phenotype	19098903	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	19098903	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	18296735	GOA
acts upstream of or within positive regulation of cell differentiation	IDA IDA: Inferred from direct assay	17576768	GOA
involved in positive regulation of miRNA transcription	IGI IGI: Inferred from genetic interaction	23764775	GOA
involved in positive regulation of smooth muscle contraction	IDA IDA: Inferred from direct assay	17215356	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17576768	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	3203386	GOA
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19783823	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	8887666	GOA
involved in response to cytokine	IMP IMP: Inferred from mutant phenotype	15180964	GOA
involved in response to hormone	IDA IDA: Inferred from direct assay	17975004	GOA
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	19098903	GOA
acts upstream of or within trophectodermal cell differentiation	IDA IDA: Inferred from direct assay	17576768	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	2108863	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRF Protein Structure

SRF-TF

0
100
200
300
400
508 a.a.

Protein Preferred Names

Protein Names

serum response factor

c-fos serum response element-binding transcription factor

SRF Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SRF	P11831	GTF2F1	Homo sapiens	P35269	Y2H	7854423
Intra	SRF	P11831	MRTFB	Homo sapiens	Q9ULH7	Anti Tag CoIP	14565952
Intra	SRF	P11831	MRTFB	Homo sapiens	Q9ULH7	Pull Down	12397177
Intra	SRF	P11831	MRTFA	Homo sapiens	Q969V6	Pull Down	12397177
Intra	SRF	P11831	MYOCD	Homo sapiens	Q8IZQ8	Comig Non-Denat Gel	12397177

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Miller Fisher Syndrome

Cranial Variant Of Gbs	Fisher'S Syndrome
Miller-Fisher Variant Of Guillain-Barre Syndrome	Miller-Fisher Syndrome
Cranial Variant Of Guillain-Barré Syndrome	Cranial Variant Of Guillain-Barre Syndrome
Fisher Syndrome

Myopericytoma

Myofibroma

Lipoleiomyoma	Uterine Fibroids
Solitary Myofibromatosis	Myolipoma

Lymphangioleiomyomatosis

Lymphangiomyomatosis	LAM
Lung Lymphangioleiomyomatosis	Pulmonary Lymphangioleiomyomatosis
Lymphangioleiomyomatosis, Somatic	Lymphangio-Myomatosis

Muscle Hypertrophy

MSLHP	Hypertrophy
Hypertrophy, Muscle

Acute Megakaryocytic Leukemia

Acute Megakaryoblastic Leukemia	Acute Megakaryoblastic Leukaemia
Megakaryocytic Myelosis	Thrombocytic Leukaemia
Amkl	Aml M7
Acute Myeloblastic Leukemia Type 7	Acute Myeloid Leukemia M7
Megakaryoblastic Leukemia Acute	Leukemia, Megakaryoblastic, Acute
Acute Myeloid Leukaemia, M7	Acute Megakaryocytic Leukaemia
Acute Megakaryoblastic Leukaemia, Fab M7	Fab M7
Malignant Megakaryocytosis	M7 - Acute Megakaryoblastic Leukaemia
Megakaryoblastic Leukaemia	Megakaryocytic Leukaemia
Acute Megakaryoblastic Leukaemia, Nos	Acute Megakaryoblastic Leukaemia Without Mention Of Remission

Chondroid Lipoma

Megabladder, Congenital

MGBL	Congenital Megabladder

Rheumatoid Vasculitis

Brachydactyly, Type E1

Brachydactyly Type E1	Brachydactyly Type E
BDE1	Brachydactyly, Type E
Bde	Type E Brachydactyly
Brachydactyly E1	Brachydactyly Syndrome Type E

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Dyslexia

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Aortic Valve Disease 1

Aortic Valve Disease	Bicuspid Aortic Valve
Aortic Valve Disorder	AOVD1
Bav	Bicuspid Aortic Valve Disease
Familial Bicuspid Aortic Valve	Aortic Valve Calcification
Aovd	Aortic Valve, Bicuspid
Aortic Valve, Calcification Of	Aortic Stenosis, Calcific
Familial Bav	Calcific Aortic Stenosis
Calcification Of Aortic Valve	Abnormality Of The Aortic Valve
Aortic Valve Disease, Type 1	Aortic Valve Disease 2
Bicommissural Aortic Valve

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm	Annuloaortic Ectasia
Familial Thoracic Aortic Aneurysm And Aortic Dissection	Familial Aortic Dissection
Familial Taad	Familial Thoracic Aortic Aneurysm
Congenital Aneurysm Of Ascending Aorta	Familial Aortic Aneurysm
Familial Thoracic Aortic Aneurysm And Dissection	Aortic Aneurysm, Thoracic
AAT1	Faa1
Aortic Dissection, Familial	Aortic Aneurysm, Familial Thoracic
Aneurysm, Thoracic Aortic	Faa
Ftaad	Taa
Taad	Cystic Medial Necrosis Of Aorta
Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection	Aortic Aneurysm Thoracic
Familial Aortic Aneurysms	Aneurysm, Aortic, Thoracic, Familial, Type 1
Aneurysm Of Thoracic Aorta	Intrathoracic Aneurysm
Thoracic Aorta Aneurysm	Thoracic Aortic Aneurysm Without Rupture
Thoracic Aneurysm	Thorax Arterial Aneurysm
Thoracic Artery Aneurysm	Thoracic Arterial Aneurysm
Thorax Aneurysm	Thorax Aortic Aneurysm
Dissection Of Thoracic Aorta

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Tetralogy Of Fallot

TOF	Fallot Tetralogy
Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle	Tetrad Of Fallot
Fallot Tetrad	Fallot Disease
Fallot Complex	Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy
Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle	Interventricular Septal Defect, In Tetralogy Of Fallot
Ventricular Septal Defect With Obstructed Right Ventricular Outflow	Tof - [Tetralogy Of Fallot]
Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]	Pulmonary Atresia, Ventricular Septal Defect And Mapcas
Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990024	Casdozokitug	Inhibitor	96.49%	Phase 2
HY-P99533	Urabrelimab	Inhibitor	98.49%	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13991	CCG-1423		99.94%	Unkown
HY-108361	CCG-203971	Inhibitor	≥98.0%	Unkown
HY-120855	CCG-100602	Inhibitor	99.85%	Unkown
HY-153078	MRTF/SRF-IN-1	Inhibitor	99.68%	Unkown
HY-111432	CCG-232601	Inhibitor	99.00%	Unkown
HY-118748	Suprafenacine	Inhibitor	≥98.0%	Unkown
HY-130011	CCG-232964	Inhibitor	/	Unkown
HY-162904	BPU17		/	Unkown
HY-162968	MRTF-A-IN-1	Inhibitor	/	Unkown
HY-162969	MRTF-A-IN-2	Inhibitor	/	Unkown
HY-RS13760	SRF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SRF	RGD	RGD:1559787
Mus musculus	SRF	MGD	MGI:106658
Macaca mulatta	SRF	VGNC	VGNC:77882
Canis familiaris	SRF	VGNC	VGNC:46799
Bos taurus	SRF	VGNC	VGNC:35277
Felis catus	SRF	VGNC	VGNC:65678
Others	SRF	NCBI

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