ADGRB1 - adhesion G protein-coupled receptor B1 Gene

Homo sapiens

Also known as BAI1; GDAIF

Gene ID: 575 | Gene type: protein coding

About ADGRB1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:142,449,649-142,545,007 (from NCBI)

This gene has 6 transcripts (splice variants), 271 orthologues and 42 paralogues. Biased expression in brain (RPKM 8.6), spleen (RPKM 1.3) and 4 other tissues.

Summary

Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the Secretin Receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]

ADGRB1 Products(5)

mRNA	Protein	Name
NM_001391985.1	NP_001378914.1	adhesion G protein-coupled receptor B1 isoform 2 precursor
NM_001391986.1	NP_001378915.1	adhesion G protein-coupled receptor B1 isoform 3 precursor
NM_001391987.1	NP_001378916.1	adhesion G protein-coupled receptor B1 isoform 4
NM_001391988.1	NP_001378917.1	adhesion G protein-coupled receptor B1 isoform 5
NM_001702.3	NP_001693.2	adhesion G protein-coupled receptor B1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	23782696	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9790924	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in apoptotic cell clearance	IMP IMP: Inferred from mutant phenotype	24509909	GOA
involved in engulfment of apoptotic cell	IMP IMP: Inferred from mutant phenotype	24509909	GOA
involved in negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	15782143	GOA
involved in negative regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	15782143	GOA
involved in positive regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	26838550	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	15782143	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	26838550	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	26838550	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADGRB1 Protein Structure

TSP_1

HRM

GPS

7tm_2

0
300
600
900
1200
1584 a.a.

Protein Preferred Names

Protein Names

adhesion G protein-coupled receptor B1

brain-specific angiogenesis inhibitor 1

Related Diseases

Diseases

Alias

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Carey-Fineman-Ziter Syndrome 1

Carey-Fineman-Ziter Syndrome	CFZS
Congenital Nonprogressive Myopathy With Moebius And Robin Sequences	Myopathy, Congenital Nonprogressive, With Moebius Sequence And Robin Sequence
Cfz Syndrome	Carey Fineman Ziter Syndrome
Myopathy, Congenital Nonprogressive With Moebius And Robin Sequences	Myopathy-Moebius-Robin Syndrome
CFZS1	Moebius Sequence, Robin Complex, And Hypotonia
Congenital Non-Progressive Myopathy With Moebius And Robin Sequences

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-131031	KCC-07		99.95%	Unkown
HY-RS00345	ADGRB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ADGRB1	MGD	MGI:1933736
Felis catus	ADGRB1	VGNC	VGNC:69071
Canis familiaris	ADGRB1	VGNC	VGNC:58288
Rattus norvegicus	ADGRB1	RGD	RGD:1305608
Bos taurus	ADGRB1	VGNC	VGNC:25658
Macaca mulatta	ADGRB1	VGNC	VGNC:69597

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