LRRC7 - leucine rich repeat containing 7 Gene

Homo sapiens

Also known as DENSIN

Gene ID: 57554 | Gene type: protein coding

About LRRC7

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:69,567,922-70,144,364 (from NCBI)

This gene has 14 transcripts (splice variants), 208 orthologues and 31 paralogues. Biased expression in brain (RPKM 2.3), testis (RPKM 0.6) and 2 other tissues.

Summary

Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; positive regulation of neuron projection development; and receptor clustering. Located in several cellular components, including centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

LRRC7 Products(10)

mRNA	Protein	Name
NM_001330635.3	NP_001317564.1	leucine-rich repeat-containing protein 7 isoform 2
NM_001350216.3	NP_001337145.1	leucine-rich repeat-containing protein 7 isoform 3
NM_001366836.3	NP_001353765.1	leucine-rich repeat-containing protein 7 isoform 4
NM_001366837.3	NP_001353766.1	leucine-rich repeat-containing protein 7 isoform 5
NM_001366838.3	NP_001353767.1	leucine-rich repeat-containing protein 7 isoform 6
NM_001366839.3	NP_001353768.1	leucine-rich repeat-containing protein 7 isoform 7
NM_001366840.1	NP_001353769.1	leucine-rich repeat-containing protein 7 isoform 8
NM_001366841.1	NP_001353770.1	leucine-rich repeat-containing protein 7 isoform 9
NM_001366842.1	NP_001353771.1	leucine-rich repeat-containing protein 7 isoform 10
NM_001370785.2	NP_001357714.1	leucine-rich repeat-containing protein 7 isoform 11

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12390249	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRC7 Protein Structure

LRR_1

LRR_4

LRR_8

LRR_4

PDZ

0
300
600
900
1200
1537 a.a.

Protein Preferred Names

Protein Names

leucine-rich repeat-containing protein 7

densin-180

Related Diseases

Diseases

Alias

Psoriasis 9

PSORS9	Psoriasis 9, Susceptibility To
Psoriasis Susceptibility 9

Cri-Du-Chat Syndrome

5p Deletion Syndrome	5p Partial Monosomy Syndrome
Monosomy 5p	Cat Cry Syndrome
Chromosome 5p Deletion Syndrome	Cri Du Chat Syndrome
5p- Syndrome	5p Minus Syndrome
Chromosome 5p- Syndrome	Chromosome 5 Short Arm Deletion Syndrome
Chromosome 5p Deletion	Deletion 5p
Cri Du Chat	5p Partial Deletion Syndrome
Partial Deletion Of Short Arm Of Chromosome 5 Syndrome

Hypomelanosis Of Ito

Incontinentia Pigmenti Achromians	Nevus Of Ito
Ipa	Ito Hypomelanosis
Ito	Pigmentation Disorders
HMI	Incontinentia Pigmenti, Type I, Formerly
Ip1, Formerly	Bloch-Siemans Syndrome
Incontinentia Pigmenti Achromians Syndrome	Ito'S Nevus
Incontinentia Pigmenti Type 1	Nevi Of Ito
Nevus Fuscocaeruleus Acromiodeltoideus	Bloch Sulzberger Syndrome
Skin Pigmentation Disorder

Trichorhinophalangeal Syndrome, Type Ii

Langer-Giedion Syndrome	Lgs
Trichorhinophalangeal Syndrome Type Ii	Trichorhinophalangeal Syndrome Type 2
TRPS2	Monosomy 8q24.1
Chromosome 8q24.1 Deletion Syndrome	Deletion 8q24.1
Giedion-Langer Syndrome	Trichorhinophalangeal Dysplasia Type Ii
Langer Giedion Syndrome	Trps 2
Tricho-Rhino-Phalangeal Syndrome Type Ii	Trichorhinophalangeal Syndrome With Exostosis
Trps Ii	Tricho-Rhino-Phalangeal Syndrome 2
8q24.1 Microdeletion Syndrome	8q24.1 Deletion Syndrome

Galloway-Mowat Syndrome

Galloway Mowat Syndrome	Galloway Syndrome
Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type	Microcephaly Nephrosis Syndrome
Microcephaly, Hiatal Hernia, And Nephrotic Syndrome	Nephrosis Neuronal Dysmigration Syndrome
Microcephaly-Hiatus Hernia-Nephrotic Syndrome	Nephrosis-Neuronal Dysmigration Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07826	LRRC7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LRRC7	RGD	RGD:708527
Canis familiaris	LRRC7	VGNC	VGNC:54044
Mus musculus	LRRC7	MGD	MGI:2676665
Felis catus	LRRC7	VGNC	VGNC:107575
Macaca mulatta	LRRC7	VGNC	VGNC:100002
Bos taurus	LRRC7	VGNC	VGNC:55251

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