Cnksr2 - connector enhancer of kinase suppressor of Ras 2 Gene

Rattus norvegicus

Gene ID: 59322 | Gene type: protein coding

About Cnksr2

Summary

Enables identical protein binding activity. Involved in postsynapse organization. Located in several cellular components, including neuronal cell body; postsynaptic density; and postsynaptic membrane. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in syndromic X-linked mental retardation Hough type. Orthologous to human CNKSR2 (connector enhancer of kinase suppressor of Ras 2). [provided by Alliance of Genome Resources, Apr 2022]

Cnksr2 Products(2)

mRNA	Protein	Name
NM_001113366.1	NP_001106837.1	connector enhancer of kinase suppressor of ras 2 isoform 1
NM_021686.3	NP_067718.1	connector enhancer of kinase suppressor of ras 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	12390249	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12390249	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in postsynapse organization	IDA IDA: Inferred from direct assay	24656827	RGD
involved in postsynapse organization	IMP IMP: Inferred from mutant phenotype	24656827	RGD
involved in postsynaptic specialization organization	IDA IDA: Inferred from direct assay	32235845	RGD
involved in postsynaptic specialization organization	IMP IMP: Inferred from mutant phenotype	32235845	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in extrinsic component of postsynaptic density membrane	IDA IDA: Inferred from direct assay	10207009	RGD
is active in extrinsic component of postsynaptic density membrane	IMP IMP: Inferred from mutant phenotype	10207009	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	10207009	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	10207009	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	10207009	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	10207009	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

connector enhancer of kinase suppressor of ras 2

CNK homolog protein 2	CNK2
connector enhancer of KSR 2	maguin
maguin-1	maguin-2
membrane-associated guanylate kinase-interacting protein

Cnksr2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Cnksr2	Q9Z1T4	Dlg4	Rattus norvegicus	P31016	Anti Bait CoIP	12390249
Intra	Cnksr2	Q9Z1T4	LRRC7	Homo sapiens	Q96NW7	Pull Down	12390249
Intra	Cnksr2	Q9Z1T4	Lrrc7	Rattus norvegicus	P70587	Anti Bait CoIP	12390249
Intra	Cnksr2	Q9Z1T4	Cnksr2	Rattus norvegicus	Q9Z1T4	Y2H	12390249
Intra	Cnksr2	Q9Z1T4	Cnksr2	Rattus norvegicus	Q9Z1T4	Anti Tag CoIP	12390249

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02889	CNKSR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cnksr2	NCBI	NCBI:22866

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