FNIP2 - folliculin interacting protein 2 Gene

Homo sapiens

Also known as FNIPL; MAPO1

Gene ID: 57600 | Gene type: protein coding

About FNIP2

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:158,769,026-158,908,050 (from NCBI)

This gene has 6 transcripts (splice variants), 145 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 11.0), fat (RPKM 8.4) and 25 other tissues.

Summary

This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced Apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (HSP90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]

FNIP2 Products(4)

mRNA	Protein	Name
NM_001323916.2	NP_001310845.1	folliculin-interacting protein 2 isoform 2
NM_001346043.2	NP_001332972.1	folliculin-interacting protein 2 isoform 3
NM_001366843.1	NP_001353772.1	folliculin-interacting protein 2 isoform 4
NM_020840.3	NP_065891.1	folliculin-interacting protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase inhibitor activity	IDA IDA: Inferred from direct assay	27353360	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18403135	GOA
enables protein-folding chaperone binding	IDA IDA: Inferred from direct assay	27353360	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21209915	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	36103527	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	19914239	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	25126726	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	18663353	GOA
involved in regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	18663353	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of FNIP-folliculin RagC/D GAP	IDA IDA: Inferred from direct assay	36103527	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	18403135	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FNIP2 Protein Structure

FNIP_N

FNIP_M

FNIP_C

0
200
400
600
800
1000
1114 a.a.

Protein Preferred Names

Protein Names

folliculin-interacting protein 2

FNIP1-like protein

FNIP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FNIP2	Q9P278	FNIP1	Homo sapiens	Q8TF40	Anti Tag CoIP	18403135
Intra	FNIP2	Q9P278	FLCN	Homo sapiens	Q8NFG4	Anti Tag CoIP	18403135
Intra	FNIP2	Q9P278	FLCN	Homo sapiens	Q8NFG4	Anti Bait CoIP	18403135

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Birt-Hogg-Dube Syndrome

Hornstein-Knickenberg Syndrome	Fibrofolliculomas With Trichodiscomas And Acrochordons
BHD	Birt-Hogg-Dubé Syndrome
Multiple Fibrofolliculoma Familial	Bhd Syndrome
Birt Hogg Dube Syndrome	Hornstein-Birt-Hogg-Dubé Syndrome
Multiple Fibrofolliculomas

Familial Renal Oncocytoma

Multilocular Clear Cell Renal Cell Carcinoma

Cystadenocarcinoma Of Kidney

Renal Cystadenocarcinoma

Oncocytoma

Oxyphilic Adenoma	Follicular Adenoma, Oxyphilic Cell
Adenoma, Oxyphilic	Hurthle Cell Tumor
Oncocytic Neoplasm

Familial Renal Papillary Carcinoma

Hereditary Papillary Renal Carcinoma

Papillary Renal Cancer Hereditary

Leiomyoma Cutis

Cutaneous Leiomyoma

Leiomyoma Of The Skin

Dermis Tumor

Dermis Tumour	Neoplasm Of Dermis
Tumor Of Dermis	Tumour Of Dermis

Pneumothorax, Primary Spontaneous

Primary Spontaneous Pneumothorax	Spontaneous Pneumothorax
Familial Spontaneous Pneumothorax	PSP
Pneumothorax

Hereditary Renal Cell Carcinoma

Renal Oncocytoma

Oncocytoma, Renal	Oncocytoma Of Kidney
Renal Epithelial Oncocytic Tumor	Oncocytoma Kidney
Oncocytoma Renal	Kidney Oncocytoma

Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma	Chromophobe Carcinoma Of Kidney
Kidney Chromophobe	Renal Cell Carcinoma, Chromophobe Cell
Crcc	Chrcc
Chromophobe Renal Cell Adenocarcinoma	Chromophobe Renal Carcinoma
Chromophobe Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05024	FNIP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FNIP2	VGNC	VGNC:100228
Mus musculus	FNIP2	MGD	MGI:2683054
Rattus norvegicus	FNIP2	RGD	RGD:1562174
Canis familiaris	FNIP2	VGNC	VGNC:40936
Bos taurus	FNIP2	VGNC	VGNC:29069
Felis catus	FNIP2	VGNC	VGNC:62326

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