EP400 - E1A binding protein p400 Gene

Homo sapiens

Also known as P400; CAGH32; TNRC12

Gene ID: 57634 | Gene type: protein coding

About EP400

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:131,949,942-132,080,460 (from NCBI)

This gene has 9 transcripts (splice variants), 229 orthologues and 30 paralogues. Ubiquitous expression in testis (RPKM 8.1), ovary (RPKM 5.8) and 25 other tissues.

Summary

Predicted to enable several functions, including ATP binding activity; ATP-dependent chromatin remodeler activity; and protein antigen binding activity. Involved in histone H2A acetylation and histone H4 acetylation. Part of NuA4 Histone Acetyltransferase complex and Swr1 complex. [provided by Alliance of Genome Resources, Apr 2022]

EP400 Products(1)

mRNA	Protein	Name
NM_015409.5	NP_056224.3	E1A-binding protein p400

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16601686	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	27153538	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	27153538	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of NuA4 histone acetyltransferase complex	IDA IDA: Inferred from direct assay	14966270	GOA
part of Swr1 complex	IDA IDA: Inferred from direct assay	24463511	GOA
part of nucleosome	IDA IDA: Inferred from direct assay	27153538	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EP400 Protein Structure

HSA

SNF2_N

Helicase_C

0
500
1000
1500
2000
2500
3123 a.a.

Protein Preferred Names

Protein Names

E1A-binding protein p400

CAG repeat protein 32

EP400 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EP400	Q96L91	RUVBL2	Homo sapiens	Q9Y230	Anti Bait CoIP	16601686
Intra	EP400	Q96L91	RUVBL2	Homo sapiens	Q9Y230	Anti Tag CoIP	33961781
Intra	EP400	Q96L91	PARP1	Homo sapiens	P09874	Anti Bait CoIP	24145797
Intra	EP400	Q96L91	ALAS1	Homo sapiens	P13196	Y2H Array	25416956
Intra	EP400	Q96L91	ALAS1	Homo sapiens	P13196	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ossifying Fibromyxoid Tumor

Ossifying Fibromyxoid Tumour

Ossifying Fibromyxoma

Endometrial Stromal Sarcoma

Ess	Endometrial Stromal Sarcoma, High Grade
Undifferentiated Endometrial Sarcoma	Stromal Sarcoma Of The Corpus Uteri
Sarcoma Endometrial Stromal	Sarcoma, Endometrial Stromal
Undifferentiated Stromal Sarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04408	EP400 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EP400	VGNC	VGNC:97765
Mus musculus	EP400	MGD	MGI:1276124
Canis familiaris	EP400	VGNC	VGNC:40390
Bos taurus	EP400	VGNC	VGNC:28517
Rattus norvegicus	EP400	RGD	RGD:1304733

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