CALCOCO1 - calcium binding and coiled-coil domain 1 Gene

Homo sapiens

Also known as Cocoa; PP13275; calphoglin

Gene ID: 57658 | Gene type: protein coding

About CALCOCO1

This gene has 22 transcripts (splice variants), 256 orthologues and 2 paralogues. Ubiquitous expression in skin (RPKM 52.1), lung (RPKM 44.3) and 25 other tissues.

Summary

Enables several functions, including armadillo repeat domain binding activity; beta-catenin binding activity; and nuclear receptor coactivator activity. Involved in positive regulation of gene expression and positive regulation of transcription, DNA-templated. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

CALCOCO1 Products(2)

mRNA	Protein	Name
NM_001143682.2	NP_001137154.1	calcium-binding and coiled-coil domain-containing protein 1 isoform 2
NM_020898.3	NP_065949.1	calcium-binding and coiled-coil domain-containing protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	24245781	GOA
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	16344550	GOA
enables nuclear receptor coactivator activity	IDA IDA: Inferred from direct assay	16344550	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16344550	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	16344550	GOA
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	16344550	GOA
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	16344550	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16344550	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	16344550	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CALCOCO1 Protein Structure

CALCOCO1

0
200
400
600
691 a.a.

Protein Preferred Names

Protein Names

calcium-binding and coiled-coil domain-containing protein 1

coiled-coil coactivator protein

CALCOCO1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CALCOCO1	Q9P1Z2	TBC1D15	Homo sapiens	Q8TC07	Validated Y2H	25416956
Intra	CALCOCO1	Q9P1Z2	TBC1D15	Homo sapiens	Q8TC07	Y2H Array	25416956
Intra	CALCOCO1	Q9P1Z2	TBC1D15	Homo sapiens	Q8TC07	Y2H Prey Pooling	25416956
Intra	CALCOCO1	Q9P1Z2	ISOC1	Homo sapiens	Q96CN7	Validated Y2H	25416956
Intra	CALCOCO1	Q9P1Z2	ISOC1	Homo sapiens	Q96CN7	Y2H Prey Pooling	25416956
Intra	CALCOCO1	Q9P1Z2	CWF19L2	Homo sapiens	Q2TBE0	Y2H Prey Pooling	25416956
Intra	CALCOCO1	Q9P1Z2	CWF19L2	Homo sapiens	Q2TBE0	Validated Y2H	25416956
Intra	CALCOCO1	Q9P1Z2	NDC80	Homo sapiens	O14777	Validated Y2H	25416956
Intra	CALCOCO1	Q9P1Z2	GABARAPL2	Homo sapiens	P60520	Validated Y2H	25416956
Intra	CALCOCO1	Q9P1Z2	CEP19	Homo sapiens	Q96LK0	Y2H Prey Pooling	25416956
Intra	CALCOCO1	Q9P1Z2	DUSP13B	Homo sapiens	Q9UII6	Validated Y2H	25416956
Intra	CALCOCO1	Q9P1Z2	DUSP13B	Homo sapiens	Q9UII6	Validated Y2H	32296183
Intra	CALCOCO1	Q9P1Z2	DUSP13B	Homo sapiens	Q9UII6	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01830	CALCOCO1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CALCOCO1	MGD	MGI:1914738
Macaca mulatta	CALCOCO1	VGNC	VGNC:70668
Felis catus	CALCOCO1	VGNC	VGNC:60319
Rattus norvegicus	CALCOCO1	RGD	RGD:619812
Canis familiaris	CALCOCO1	VGNC	VGNC:38662
Bos taurus	CALCOCO1	VGNC	VGNC:26702

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