NDC80 - NDC80 kinetochore complex component Gene

Homo sapiens

Also known as HEC; HEC1; TID3; KNTC2; HsHec1; hsNDC80

Gene ID: 10403 | Gene type: protein coding

About NDC80

Cytogenetic location: 18p11.32 Genomic coordinates (GRCh38): 18:2,571,557-2,616,635 (from NCBI)

This gene has 5 transcripts (splice variants) and 208 orthologues. Broad expression in testis (RPKM 8.6), lymph node (RPKM 8.5) and 16 other tissues.

Summary

This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]

NDC80 Products(1)

mRNA	Protein	Name
NM_006101.3	NP_006092.1	kinetochore protein NDC80 homolog

NDC80 Protein Structure

Ndc80_HEC

0
100
200
300
400
500
600
642 a.a.

Protein Preferred Names

Protein Names

kinetochore protein NDC80 homolog

NDC80 homolog, kinetochore complex component

Related Diseases

Diseases

Alias

Endometrial Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Endometrium	Adenosquamous Carcinoma Of The Endometrium
Endometrial Adenosquamous Cancer	Endometrial Adenosquamous Cell Carcinoma

Endometrial Adenocarcinoma

Endometrial Endometrioid Adenocarcinoma	Endometrial Adenoacanthoma
Endometrial Endometrioid Adenocarcinoma, Variant With Squamous Differentiation	Adenocarcinoma Of Endometrium
Adenocarcinoma Of The Endometrium	Adenocarcinoma Of Uterus
Endometrial Endometrioid Adenocarcinoma With Squamous Differentiation	Endometrioid Adenoma Or Carcinoma
Endometrioid Adenomas And Carcinomas	Endometrioid Carcinoma Of Endometrium
Endometrium Adenocarcinoma

Intellectual Developmental Disorder, Autosomal Dominant 1

MRD1	Autosomal Dominant Non-Syndromic Intellectual Disability 1
Mental Retardation, Autosomal Dominant 1	Autosomal Dominant Intellectual Developmental Disorder 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09105	NDC80 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NDC80	MGD	MGI:1914302
Canis familiaris	NDC80	VGNC	VGNC:43670
Rattus norvegicus	NDC80	RGD	RGD:1310154
Bos taurus	NDC80	VGNC	VGNC:31931
Felis catus	NDC80	VGNC	VGNC:63747
Macaca mulatta	NDC80	VGNC	VGNC:74975

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