LRRC4C - leucine rich repeat containing 4C Gene

Homo sapiens

Also known as NGL1; NGL-1

Gene ID: 57689 | Gene type: protein coding

About LRRC4C

Cytogenetic location: 11p12 Genomic coordinates (GRCh38): 11:40,114,199-41,459,652 (from NCBI)

This gene has 7 transcripts (splice variants), 257 orthologues and 22 paralogues. Biased expression in brain (RPKM 5.3), adrenal (RPKM 0.7) and 1 other tissue.

Summary

NGL1 is a specific binding partner for netrin G1 (NTNG1; MIM 608818), which is a member of the netrin family of axon guidance molecules (Lin et al., 2003 [PubMed 14595443]).[supplied by OMIM, Mar 2008]

LRRC4C Products(2)

mRNA	Protein	Name
NM_001258419.2	NP_001245348.1	leucine-rich repeat-containing protein 4C precursor
NM_020929.3	NP_065980.1	leucine-rich repeat-containing protein 4C precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	23986473	GOA
enables cell-cell adhesion mediator activity	IGI IGI: Inferred from genetic interaction	23986473	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14595443	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of axonogenesis	IDA IDA: Inferred from direct assay	14595443	GOA
involved in synaptic membrane adhesion	IGI IGI: Inferred from genetic interaction	23986473	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	14595443	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRC4C Protein Structure

LRR_5

LRR_1

LRR_8

I-set

0
100
200
300
400
500
600
640 a.a.

Protein Preferred Names

Protein Names

leucine-rich repeat-containing protein 4C

netrin-G1 ligand

Recombinant LRRC4C Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77102	NGL-1/LRRC4C Protein, Human (527a.a, HEK293, His)	Q9HCJ2/NP_001245348.1 (Q45-K527)	≥95%

Related Diseases

Diseases

Alias

Developmental And Epileptic Encephalopathy 2

Epileptic Encephalopathy, Early Infantile, 2	DEE2
Eiee2	Issx2
Developmental And Epileptic Encephalopathy, 2	Infantile Spasm Syndrome, X-Linked 2
Early Infantile Epileptic Encephalopathy 2	X-Linked Infantile Spasm Syndrome 2
Atypical Rett Syndrome Cdkl5-Related	Atypical Rett Syndrome Hanefeld Variant
Infantile Spasm Syndrome X-Linked 2	Rett Syndrome Early-Onset Seizure Variant
Rett Syndrome Variant With Infantile Spasms	Encephalopathy, Epileptic, Early Infantile, Type 2

Colon Mucinous Adenocarcinoma

Colonic Mucinous Adenocarcinoma

Mucinous Adenocarcinoma Of The Colon

Developmental And Epileptic Encephalopathy 1

Epileptic Encephalopathy, Early Infantile, 1	Infantile Epileptic-Dyskinetic Encephalopathy
DEE1	Eiee1
Issx1	Xmesid
X-Linked Infantile Spasm Syndrome 1	X-Linked Infantile Spasm Syndrome
X-Linked Spasticity-Intellectual Disability-Epilepsy Syndrome	Developmental And Epileptic Encephalopathy, 1
Infantile Epileptic Dyskinetic Encephalopathy	Infantile Spasm Syndrome, X-Linked 1
West Syndrome, X-Linked	Ohtahara Syndrome, X-Linked
Early Infantile Epileptic Encephalopathy 1	Early Infantile Epileptic Encephalopathy-1
Issx	X-Linked Ohtahara Syndrome
X-Linked West Syndrome	Infantile Spasm Syndrome X-Linked 1
Myoclonic Epilepsy X-Linked With Intellectual Disability And Spasticity	Ohtahara Syndrome X-Linked
West Syndrome X-Linked	Encephalopathy, Epileptic, Early Infantile, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07822	LRRC4C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LRRC4C	VGNC	VGNC:74391
Canis familiaris	LRRC4C	VGNC	VGNC:42803
Bos taurus	LRRC4C	VGNC	VGNC:31020
Rattus norvegicus	LRRC4C	RGD	RGD:1311013
Felis catus	LRRC4C	VGNC	VGNC:63304
Mus musculus	LRRC4C	MGD	MGI:2442636
Others	LRRC4C	NCBI

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