MIER1 - MIER1 transcriptional regulator Gene

Homo sapiens

Also known as ER1; MI-ER1

Gene ID: 57708 | Gene type: protein coding

About MIER1

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:66,924,990-66,988,619 (from NCBI)

This gene has 11 transcripts (splice variants), 223 orthologues and 5 paralogues. Ubiquitous expression in bone marrow (RPKM 19.6), colon (RPKM 10.3) and 24 other tissues.

Summary

This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]

MIER1 Products(12)

mRNA	Protein	Name
NM_001077700.3	NP_001071168.2	mesoderm induction early response protein 1 isoform b
NM_001077701.3	NP_001071169.1	mesoderm induction early response protein 1 isoform c
NM_001077702.3	NP_001071170.2	mesoderm induction early response protein 1 isoform d precursor
NM_001077703.3	NP_001071171.2	mesoderm induction early response protein 1 isoform e
NM_001077704.3	NP_001071172.1	mesoderm induction early response protein 1 isoform f
NM_001146110.2	NP_001139582.1	mesoderm induction early response protein 1 isoform a precursor
NM_001146111.2	NP_001139583.1	mesoderm induction early response protein 1 isoform g precursor
NM_001146112.2	NP_001139584.1	mesoderm induction early response protein 1 isoform h
NM_001146113.2	NP_001139585.1	mesoderm induction early response protein 1 isoform i
NM_001278215.2	NP_001265144.1	mesoderm induction early response protein 1 isoform j precursor
NM_001350530.2	NP_001337459.1	mesoderm induction early response protein 1 isoform k
NM_020948.4	NP_065999.2	mesoderm induction early response protein 1 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to histone deacetylase activity	IDA IDA: Inferred from direct assay	28046085	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	28046085	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12482978	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	12482978	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12482978	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	28046085	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	28046085	GOA
part of transcription repressor complex	IDA IDA: Inferred from direct assay	12482978	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MIER1 Protein Structure

ELM2

0
100
200
300
400
512 a.a.

Protein Preferred Names

Protein Names

mesoderm induction early response protein 1

mesoderm induction early response 1 homolog

Related Diseases

Diseases

Alias

Inflammatory Bowel Disease 2

IBD2

Frozen Shoulder

Adhesive Capsulitis Of Shoulder	Bursitis
Adhesions-Capsulitis,Shoulder	Pericapsulitis Of Shoulder
Duplay Bursitis	Adhesive Shoulder Peritendinitis
Subscapular Adhesion	Shoulder Adhesion
Adhesive Enthesopathy Of Shoulder Region	Adhesive Peritendinitis
Adhesive Shoulder Tenosynovitis	Duplay Periarthritis
Adhesive Shoulder Tendinitis

Amelogenesis Imperfecta, Type Ig

Enamel-Renal Syndrome	Ers
Amelogenesis Imperfecta Type 1g	AI1G
Enamel-Renal-Gingival Syndrome	Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome
Aigfs	Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis
Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis	Amelogenesis Imperfecta Type Ig
Amelogenesis Imperfecta-Nephrocalcinosis Syndrome	Amelogenesis Imperfecta 1g
Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis	Amelogenesis Imperfecta Nephrocalcinosis

Calcific Tendinitis

Calcific Tendinitis Nos

Teeth Hard Tissue Disease

Amelogenesis Imperfecta

Ai	Congenital Enamel Hypoplasia
Al - [Amelogenesis Imperfecta]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08442	MIER1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MIER1	VGNC	VGNC:31469
Canis familiaris	MIER1	VGNC	VGNC:43229
Felis catus	MIER1	VGNC	VGNC:63500
Macaca mulatta	MIER1	VGNC	VGNC:74862
Rattus norvegicus	MIER1	RGD	RGD:1562337
Mus musculus	MIER1	MGD	MGI:1918398

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