Jmy - junction-mediating and regulatory protein Gene

Mus musculus

Gene ID: 57748 | Gene type: protein coding

About Jmy

Summary

Enables transcription coactivator activity. Involved in several processes, including actin nucleation; actin polymerization-dependent cell motility; and positive regulation of DNA-binding transcription factor activity. Acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in skeletal muscle. Orthologous to human JMY (junction mediating and regulatory protein, p53 cofactor). [provided by Alliance of Genome Resources, Apr 2022]

Jmy Products(1)

mRNA	Protein	Name
NM_021310.3	NP_067285.2	junction-mediating and -regulatory protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10518217	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	10518217	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in 'de novo' actin filament nucleation	IDA IDA: Inferred from direct assay	19287377	MGI
involved in Arp2/3 complex-mediated actin nucleation	IDA IDA: Inferred from direct assay	19287377	MGI
involved in actin polymerization-dependent cell motility	IDA IDA: Inferred from direct assay	19287377	MGI
acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator	IDA IDA: Inferred from direct assay	10518217	MGI
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	10518217	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10518217	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	19287377	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

junction-mediating and -regulatory protein

p300 transcriptional cofactor JMY

Jmy Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Jmy	Q9QXM1	EP300	Homo sapiens	Q09472	Anti Bait CoIP	10518217
Cross	Jmy	Q9QXM1	EP300	Homo sapiens	Q09472	Y2H	10518217
Cross	Jmy	Q9QXM1	EP300	Homo sapiens	Q09472	Pull Down	10518217

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07042	JMY Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Jmy	NCBI	NCBI:133746

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