PTPN13 - protein tyrosine phosphatase non-receptor type 13 Gene

Homo sapiens

Also known as PNP1; FAP-1; PTP1E; PTPL1; PTPLE; PTP-BL; hPTP1E; PTP-BAS

Gene ID: 5783 | Gene type: protein coding

About PTPN13

Cytogenetic location: 4q21.3 Genomic coordinates (GRCh38): 4:86,594,315-86,815,161 (from NCBI)

This gene has 9 transcripts (splice variants), 208 orthologues, 35 paralogues and is associated with 98 phenotypes. Broad expression in skin (RPKM 27.0), ovary (RPKM 14.2) and 18 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]

PTPN13 Products(4)

mRNA	Protein	Name
NM_006264.3	NP_006255.1	tyrosine-protein phosphatase non-receptor type 13 isoform 2
NM_080683.3	NP_542414.1	tyrosine-protein phosphatase non-receptor type 13 isoform 1
NM_080684.3	NP_542415.1	tyrosine-protein phosphatase non-receptor type 13 isoform 3
NM_080685.3	NP_542416.1	tyrosine-protein phosphatase non-receptor type 13 isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidylinositol 3-kinase regulatory subunit binding	IPI IPI: Inferred from physical interaction	23604317	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10826496	GOA
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	14516276	GOA
enables protein tyrosine phosphatase activity	IMP IMP: Inferred from mutant phenotype	23604317	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	25893857	GOA
involved in peptidyl-tyrosine dephosphorylation	IMP IMP: Inferred from mutant phenotype	23604317	GOA
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	17657516	GOA
involved in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	23604317	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14516276	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	11356191	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10826496	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	14516276	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN13 Protein Structure

FERM_N

FERM_M

FERM_C

PDZ

Y_phosphatase

0
400
800
1200
1600
2000
2485 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein phosphatase non-receptor type 13

fas-associated protein-tyrosine phosphatase 1

PTPN13 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PTPN13	Q12923	RAPGEF6	Homo sapiens	Q8TEU7	X-Ray Diffraction	12095257
Intra	PTPN13	Q12923	RAPGEF6	Homo sapiens	Q8TEU7	NMR	14698303
Intra	PTPN13	Q12923	RAPGEF6	Homo sapiens	Q8TEU7	ITC	17240990
Intra	PTPN13	Q12923	FAS	Homo sapiens	P25445	Anti Tag CoIP	12724420
Intra	PTPN13	Q12923	PDCD10	Homo sapiens	Q9BUL8	Y2H	17657516

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Streptococcal Meningitis

Colorectal Cancer, Hereditary Nonpolyposis, Type 6

HNPCC6	Hereditary Nonpolyposis Colorectal Cancer Type 6
Colon Cancer, Hereditary Nonpolyposis, Type 6	Hereditary Non-Polyposis Colorectal Cancer 6
Cancer, Colorectal, Nonpolyposis, Hereditary, Type 6

Rectum Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Rectum	Rectal Squamous Cell Carcinoma
Squamous Carcinoma Of Rectum

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Cavernous Angioma	Familial Cerebral Cavernous Malformation
Cerebral Cavernous Malformations 1	Cavernous Angioma, Familial
Cam	Cerebral Cavernous Malformations-1
Cavernoma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Colorectal Cancer, Hereditary Nonpolyposis, Type 4

HNPCC4	Hereditary Nonpolyposis Colorectal Cancer Type 4
Hereditary Non-Polyposis Colorectal Cancer 4	Cancer, Colorectal, Nonpolyposis, Hereditary, Type 4

Subacute Bacterial Endocarditis

Endocarditis Lenta	Sbe - Subacute Bacterial Endocarditis
Subacute Endocarditis, Lenta	Endocarditis, Subacute Bacterial

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Lynch Syndrome I

Lynch Syndrome 1	Colorectal Cancer, Hereditary Nonpolyposis, Type 1
HNPCC1	Fcc1
Lynch Syndrome Ii	Colon Cancer, Familial Nonpolyposis, Type 1
Coca1	Familial Nonpolyposis Colon Cancer Type 1
Hereditary Nonpolyposis Colorectal Cancer Type 1	Hereditary Non-Polyposis Colorectal Cancer 1
Hereditary Non-Polyposis Colorectal Cancer 3	Hnpcc3
Lynch Cancer Family Syndrome	Lynch Syndrome
Lynch Syndrome Type I	Lynch Syndrome Type Ii
Cancer, Colorectal, Nonpolyposis, Hereditary, Type 1	Hereditary Nonpolyposis Colorectal Cancer
Colorectal Cancer, Hereditary Nonpolyposis, Type 3	Hereditary Non-Polyposis Colon Cancer Type 2

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11418	PTPN13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PTPN13	VGNC	VGNC:45170
Macaca mulatta	PTPN13	VGNC	VGNC:76599
Mus musculus	PTPN13	MGD	MGI:103293
Felis catus	PTPN13	VGNC	VGNC:69160
Bos taurus	PTPN13	VGNC	VGNC:53774
Rattus norvegicus	PTPN13	RGD	RGD:1563360

Name
Email *

	Sorry, but the email address you supplied was invalid.