2. Gene
  3. CADM3 - cell adhesion molecule 3 Gene

CADM3 - cell adhesion molecule 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BIgR; NECL1; TSLL1; CMT2FF; IGSF4B; Necl-1; synCAM3

Gene ID: 57863 | Gene type: protein coding

About CADM3

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:159,171,615-159,203,313 (from NCBI)

This gene has 3 transcripts (splice variants), 202 orthologues, 14 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 106.6), placenta (RPKM 39.2) and 4 other tissues.

Summary

The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with Other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is reported to be a tumor suppressor gene. [provided by RefSeq, Oct 2016]

CADM3 Products(3)

mRNA Protein Name
NM_001127173.3 NP_001120645.1 cell adhesion molecule 3 isoform 2 precursor
NM_001346510.2 NP_001333439.1 cell adhesion molecule 3 isoform 3 precursor
NM_021189.5 NP_067012.1 cell adhesion molecule 3 isoform 1 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CADM3 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (37 - 117)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (135 - 218)

Ig_2

Ig_2: Immunoglobulin domain (237 - 315)

  • 0
  • 100
  • 200
  • 300
  • 398 a.a.
Protein Preferred Names Protein Names

cell adhesion molecule 3

TSLC1-like 1

CADM3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CADM3 Q8N126 SEC11C Homo sapiens Q9BY50
Y2H Prey Pooling
32296183
Intra
CADM3 Q8N126 SEC11C Homo sapiens Q9BY50
Y2H Array
32296183
Intra
CADM3 Q8N126 SEC11C Homo sapiens Q9BY50
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CADM3 Proteins

Cat. No. Product Name Accession Purity
HY-P70083 CADM3 Protein, Human (HEK293, His) Q8N126-1 (N25-H330) ≥95%

Related Diseases

Diseases Alias
Charcot-Marie-Tooth Disease, Axonal, Type 2ff

CMT2FF

Charcot-Marie-Tooth Neuropathy, Type 2ff

Charcot-Marie-Tooth Disease 2ff
Cleft Lip/Palate-Ectodermal Dysplasia Syndrome

Orofacial Cleft 7

Zlotogora-Ogur Syndrome

CLPED1

Ectodermal Dysplasia, Margarita Island Type

Ed4

Cleft Lip-Palate-Ectodermal Dysplasia Syndrome

Cleft Lip/Palate-Syndactyly-Pili Torti Syndrome

Syndactyly-Ectodermal Dysplasia-Cleft/Lip Palate

Ectodermal Dysplasia 4

Ectodermal Dysplasia Margarita Type

Ectodermal Dysplasia, Type 4

Ectodermal Dysplasia, Cleft Lip And Palate, Mental Retardation, And Syndactyly

Margarita Type Of Ectodermal Dysplasia

Zlotogora-Zilberman-Tenenbaum Syndrome

Ectd4

Ectodermal Dysplasia 4, Hair/Nail Type

EDMI

Ectodermal Dysplasia Type 4

Margarita Island Ectodermal Dysplasia

Syndactyly-Ectodermal Dysplasia-Cleft Lip/Palate

Non-Syndromic Orofacial Cleft 7

OFC7

Non-Syndromic Cleft Lip/Palate 7

Non-Syndromic Cleft Lip With Or Without Cleft Palate 7
Charcot-Marie-Tooth Disease

Cmt

Hmsn

Hereditary Motor And Sensory Neuropathy

Pma

Cmt - Charcot-Marie-Tooth Disease

Charcot Marie Tooth Disease

Charcot-Marie-Tooth Hereditary Neuropathy

Charcot-Marie-Tooth Syndrome

Peroneal Muscular Atrophy

Hereditary Motor And Sensory Neuropathies
Tooth Disease

Tooth Diseases

Teeth Disease

Tooth Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01821 CADM3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CADM3 RGD RGD:1307035
Mus musculus CADM3 MGD MGI:2137858
Canis familiaris CADM3 VGNC VGNC:38657
Bos taurus CADM3 VGNC VGNC:26696
Macaca mulatta CADM3 VGNC VGNC:70574
Felis catus CADM3 VGNC VGNC:60314
Macaca fascicularis CADM3 NCBI NCBI:102129491
Others CADM3 NCBI