2. Gene
  3. PURB - purine rich element binding protein B Gene

PURB - purine rich element binding protein B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PURBETA

Gene ID: 5814 | Gene type: protein coding

About PURB

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,876,299-44,885,530 (from NCBI)

This gene has 1 transcript (splice variant), 231 orthologues and 2 paralogues.

Summary

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]

PURB Products(1)

mRNA Protein Name
NM_033224.5 NP_150093.1 transcriptional activator protein Pur-beta
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PURB Protein Structure

PurA

PurA: PurA ssDNA and RNA-binding protein (31 - 279)

  • 0
  • 100
  • 200
  • 312 a.a.
Protein Preferred Names Protein Names

transcriptional activator protein Pur-beta

Related Diseases

Diseases Alias
Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11465 PURB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PURB MGD MGI:1338779
Felis catus PURB VGNC VGNC:80667
Macaca mulatta PURB VGNC VGNC:81749
Rattus norvegicus PURB RGD RGD:1559465
Bos taurus PURB VGNC VGNC:33573