1. Gene
  2. AP1M1 - adaptor related protein complex 1 subunit mu 1 Gene

AP1M1 - adaptor related protein complex 1 subunit mu 1 Gene

Homo sapiens

Also known as AP47; mu1A; CLTNM; MU-1A; CLAPM2

Gene ID: 8907 | Gene type: protein coding

About AP1M1

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:16,197,911-16,245,906 (from NCBI)

This gene has 15 transcripts (splice variants), 209 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 31.3), brain (RPKM 17.8) and 25 other tissues.

Summary

The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The Other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

AP1M1 Products(2)

mRNA Protein Name
NM_001130524.2 NP_001123996.1 AP-1 complex subunit mu-1 isoform 1
NM_032493.4 NP_115882.1 AP-1 complex subunit mu-1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9341158 GOA
Biological Process GO Annotation Evidence Reference Source
involved in endosome to melanosome transport IMP
IMP: Inferred from mutant phenotype
19841138 GOA
involved in melanosome organization IMP
IMP: Inferred from mutant phenotype
19841138 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AP1M1 Protein Structure

Clat_adaptor_s

Clat_adaptor_s: Clathrin adaptor complex small chain (5 - 133)

Adap_comp_sub

Adap_comp_sub: Adaptor complexes medium subunit family (157 - 421)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 423 a.a.
Protein Preferred Names Protein Names

AP-1 complex subunit mu-1

AP-mu chain family member mu1A

AP1M1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
AP1M1 Q9BXS5 PNMA5 Homo sapiens Q96PV4 25416956
Intra
AP1M1 Q9BXS5 PNMA5 Homo sapiens Q96PV4 25416956
Intra
AP1M1 Q9BXS5 KRT40 Homo sapiens Q6A162 32296183
Intra
AP1M1 Q9BXS5 KRT40 Homo sapiens Q6A162 32296183
Intra
AP1M1 Q9BXS5 KRTAP10-8 Homo sapiens P60410 32296183
Intra
AP1M1 Q9BXS5 KRTAP10-8 Homo sapiens P60410 32296183
Intra
AP1M1 Q9BXS5 KRTAP10-7 Homo sapiens P60409 25416956
Intra
AP1M1 Q9BXS5 KRTAP10-7 Homo sapiens P60409 32296183
Intra
AP1M1 Q9BXS5 KRTAP10-7 Homo sapiens P60409 32296183
Intra
AP1M1 Q9BXS5 MID2 Homo sapiens Q9UJV3-2 32296183
Intra
AP1M1 Q9BXS5 MID2 Homo sapiens Q9UJV3-2 32296183
Intra
AP1M1 Q9BXS5 MID2 Homo sapiens Q9UJV3-2 32296183
Intra
AP1M1 Q9BXS5 ZBTB14 Homo sapiens O43829 32296183
Intra
AP1M1 Q9BXS5 ZBTB14 Homo sapiens O43829 25416956
Intra
AP1M1 Q9BXS5 ZBTB14 Homo sapiens O43829 32296183
Intra
AP1M1 Q9BXS5 ENTR1 Homo sapiens Q96C92-2 25416956
Intra
AP1M1 Q9BXS5 ENTR1 Homo sapiens Q96C92-2 25416956
Intra
AP1M1 Q9BXS5 CEP57L1 Homo sapiens Q8IYX8-2 25416956
Intra
AP1M1 Q9BXS5 CEP57L1 Homo sapiens Q8IYX8-2 25416956
Intra
AP1M1 Q9BXS5 SP4 Homo sapiens Q02446 32296183
Intra
AP1M1 Q9BXS5 SP4 Homo sapiens Q02446 32296183
Intra
AP1M1 Q9BXS5 KIF24 Homo sapiens Q5T7B8-2 32296183
Intra
AP1M1 Q9BXS5 KIF24 Homo sapiens Q5T7B8-2 32296183
Intra
AP1M1 Q9BXS5 OLIG3 Homo sapiens Q7RTU3 32296183
Intra
AP1M1 Q9BXS5 OLIG3 Homo sapiens Q7RTU3 32296183
Intra
AP1M1 Q9BXS5 GCSAM Homo sapiens Q8N6F7 32296183
Intra
AP1M1 Q9BXS5 GCSAM Homo sapiens Q8N6F7 32296183
Intra
AP1M1 Q9BXS5 HOOK2 Homo sapiens Q96ED9-2 32296183
Intra
AP1M1 Q9BXS5 HOOK2 Homo sapiens Q96ED9-2 32296183
Intra
AP1M1 Q9BXS5 FXR1 Homo sapiens P51114-2 32296183
Intra
AP1M1 Q9BXS5 FXR1 Homo sapiens P51114-2 32296183
Intra
AP1M1 Q9BXS5 TFIP11 Homo sapiens Q9UBB9 32296183
Intra
AP1M1 Q9BXS5 TFIP11 Homo sapiens Q9UBB9 32296183
Intra
AP1M1 Q9BXS5 TEPSIN Homo sapiens Q96N21 32296183
Intra
AP1M1 Q9BXS5 TEPSIN Homo sapiens Q96N21 32296183
Intra
AP1M1 Q9BXS5 IKZF1 Homo sapiens Q13422-7 32296183
Intra
AP1M1 Q9BXS5 IKZF1 Homo sapiens Q13422-7 32296183
Intra
AP1M1 Q9BXS5 NECAB1 Homo sapiens Q8N987 32296183
Intra
AP1M1 Q9BXS5 NECAB1 Homo sapiens Q8N987 32296183
Intra
AP1M1 Q9BXS5 RUNDC3A Homo sapiens Q59EK9-3 32296183
Intra
AP1M1 Q9BXS5 RUNDC3A Homo sapiens Q59EK9-3 32296183
Intra
AP1M1 Q9BXS5 DISC1 Homo sapiens Q9NRI5-2 32296183
Intra
AP1M1 Q9BXS5 DISC1 Homo sapiens Q9NRI5-2 32296183
Intra
AP1M1 Q9BXS5 DISC1 Homo sapiens Q9NRI5-2 32296183
Intra
AP1M1 Q9BXS5 LZTS1 Homo sapiens Q9Y250 32296183
Intra
AP1M1 Q9BXS5 LZTS1 Homo sapiens Q9Y250 32296183
Intra
AP1M1 Q9BXS5 LZTS1 Homo sapiens Q9Y250 32296183
Intra
AP1M1 Q9BXS5 ARL6IP4 Homo sapiens A0A0C4DG62 32296183
Intra
AP1M1 Q9BXS5 ARL6IP4 Homo sapiens A0A0C4DG62 32296183
Intra
AP1M1 Q9BXS5 FAM219B Homo sapiens Q5XKK7 32296183
Intra
AP1M1 Q9BXS5 FAM219B Homo sapiens Q5XKK7 32296183
Intra
AP1M1 Q9BXS5 CASP8 Homo sapiens Q6NVI2 32296183
Intra
AP1M1 Q9BXS5 CASP8 Homo sapiens Q6NVI2 32296183
Intra
AP1M1 Q9BXS5 ZNF19 Homo sapiens P17023 32296183
Intra
AP1M1 Q9BXS5 ZNF19 Homo sapiens P17023 32296183
Intra
AP1M1 Q9BXS5 ETV6 Homo sapiens P41212 25416956
Intra
AP1M1 Q9BXS5 ROPN1 Homo sapiens Q9HAT0 32296183
Intra
AP1M1 Q9BXS5 ROPN1 Homo sapiens Q9HAT0 32296183
Intra
AP1M1 Q9BXS5 ROPN1 Homo sapiens Q9HAT0 32296183
Intra
AP1M1 Q9BXS5 BACH2 Homo sapiens Q9BYV9 32296183
Intra
AP1M1 Q9BXS5 BACH2 Homo sapiens Q9BYV9 32296183
Intra
AP1M1 Q9BXS5 BACH2 Homo sapiens Q9BYV9 32296183
Intra
AP1M1 Q9BXS5 AMOT Homo sapiens A2BDD9 32296183
Intra
AP1M1 Q9BXS5 AMOT Homo sapiens A2BDD9 32296183
Intra
AP1M1 Q9BXS5 SPATA6 Homo sapiens Q9NWH7-2 32296183
Intra
AP1M1 Q9BXS5 SPATA6 Homo sapiens Q9NWH7-2 32296183
Intra
AP1M1 Q9BXS5 SPATA6 Homo sapiens Q9NWH7-2 32296183
Intra
AP1M1 Q9BXS5 LRMDA Homo sapiens A0A087WWI0 32296183
Intra
AP1M1 Q9BXS5 LRMDA Homo sapiens A0A087WWI0 32296183
Intra
AP1M1 Q9BXS5 SSX2IP Homo sapiens Q9Y2D8 25416956
Intra
AP1M1 Q9BXS5 SSX2IP Homo sapiens Q9Y2D8 25416956
Intra
AP1M1 Q9BXS5 SSX2IP Homo sapiens Q9Y2D8 25416956
Intra
AP1M1 Q9BXS5 RNF19B Homo sapiens Q6ZMZ0 32296183
Intra
AP1M1 Q9BXS5 RNF19B Homo sapiens Q6ZMZ0 32296183
Intra
AP1M1 Q9BXS5 ZNF552 Homo sapiens Q9H707 32296183
Intra
AP1M1 Q9BXS5 ZNF552 Homo sapiens Q9H707 32296183
Intra
AP1M1 Q9BXS5 ZNF552 Homo sapiens Q9H707 32296183
Intra
AP1M1 Q9BXS5 ZNF8 Homo sapiens P17098 32296183
Intra
AP1M1 Q9BXS5 ZNF8 Homo sapiens P17098 32296183
Intra
AP1M1 Q9BXS5 PURB Homo sapiens Q96QR8 32296183
Intra
AP1M1 Q9BXS5 PURB Homo sapiens Q96QR8 32296183
Intra
AP1M1 Q9BXS5 TNIP1 Homo sapiens Q15025 25416956
Intra
AP1M1 Q9BXS5 FKBP7 Homo sapiens Q9Y680 32296183
Intra
AP1M1 Q9BXS5 FKBP7 Homo sapiens Q9Y680 32296183
Intra
AP1M1 Q9BXS5 FKBP7 Homo sapiens Q9Y680 32296183
Intra
AP1M1 Q9BXS5 NKAPD1 Homo sapiens Q6ZUT1 32296183
Intra
AP1M1 Q9BXS5 NKAPD1 Homo sapiens Q6ZUT1 32296183
Intra
AP1M1 Q9BXS5 THAP6 Homo sapiens Q8TBB0 32296183
Intra
AP1M1 Q9BXS5 THAP6 Homo sapiens Q8TBB0 32296183
Intra
AP1M1 Q9BXS5 ZNF219 Homo sapiens Q9P2Y4 32296183
Intra
AP1M1 Q9BXS5 ZNF219 Homo sapiens Q9P2Y4 32296183
Intra
AP1M1 Q9BXS5 ZNF219 Homo sapiens Q9P2Y4 32296183
Intra
AP1M1 Q9BXS5 AXIN2 Homo sapiens Q9Y2T1 32296183
Intra
AP1M1 Q9BXS5 AXIN2 Homo sapiens Q9Y2T1 32296183
Intra
AP1M1 Q9BXS5 AXIN2 Homo sapiens Q9Y2T1 32296183
Intra
AP1M1 Q9BXS5 MYOD1 Homo sapiens P15172 32296183
Intra
AP1M1 Q9BXS5 MYOD1 Homo sapiens P15172 32296183
Intra
AP1M1 Q9BXS5 ATF4 Homo sapiens P18848 32296183
Intra
AP1M1 Q9BXS5 ATF4 Homo sapiens P18848 32296183
Intra
AP1M1 Q9BXS5 ZRANB1 Homo sapiens Q9UGI0 32296183
Intra
AP1M1 Q9BXS5 ZRANB1 Homo sapiens Q9UGI0 32296183
Intra
AP1M1 Q9BXS5 ZRANB1 Homo sapiens Q9UGI0 32296183
Intra
AP1M1 Q9BXS5 ZNF655 Homo sapiens Q8N720 32296183
Intra
AP1M1 Q9BXS5 ZNF655 Homo sapiens Q8N720 32296183
Intra
AP1M1 Q9BXS5 RP9 Homo sapiens Q8TA86 32296183
Intra
AP1M1 Q9BXS5 RP9 Homo sapiens Q8TA86 32296183
Intra
AP1M1 Q9BXS5 RP9 Homo sapiens Q8TA86 32296183
Intra
AP1M1 Q9BXS5 BCAR3 Homo sapiens O75815 32296183
Intra
AP1M1 Q9BXS5 BCAR3 Homo sapiens O75815 32296183
Intra
AP1M1 Q9BXS5 PHC2 Homo sapiens Q8IXK0 25416956
Intra
AP1M1 Q9BXS5 TRIM27 Homo sapiens P14373 32296183
Intra
AP1M1 Q9BXS5 TRIM27 Homo sapiens P14373 32296183
Intra
AP1M1 Q9BXS5 NKAP Homo sapiens Q8N5F7 32296183
Intra
AP1M1 Q9BXS5 NKAP Homo sapiens Q8N5F7 32296183
Intra
AP1M1 Q9BXS5 MDK Homo sapiens P21741 32296183
Intra
AP1M1 Q9BXS5 MDK Homo sapiens P21741 32296183
Intra
AP1M1 Q9BXS5 ZBTB3 Homo sapiens Q9H5J0 32296183
Intra
AP1M1 Q9BXS5 ZBTB3 Homo sapiens Q9H5J0 32296183
Intra
AP1M1 Q9BXS5 ZBTB3 Homo sapiens Q9H5J0 32296183
Intra
AP1M1 Q9BXS5 ZSCAN16 Homo sapiens Q9H4T2 32296183
Intra
AP1M1 Q9BXS5 ZSCAN16 Homo sapiens Q9H4T2 32296183
Intra
AP1M1 Q9BXS5 ZSCAN16 Homo sapiens Q9H4T2 32296183
Intra
AP1M1 Q9BXS5 TRIM41 Homo sapiens Q8WV44 32296183
Intra
AP1M1 Q9BXS5 TRIM41 Homo sapiens Q8WV44 32296183
Intra
AP1M1 Q9BXS5 LNX1 Homo sapiens Q8TBB1 32296183
Intra
AP1M1 Q9BXS5 LNX1 Homo sapiens Q8TBB1 32296183
Intra
AP1M1 Q9BXS5 FXR2 Homo sapiens P51116 25416956
Intra
AP1M1 Q9BXS5 FXR2 Homo sapiens P51116 16189514
Intra
AP1M1 Q9BXS5 FXR2 Homo sapiens P51116 32296183
Intra
AP1M1 Q9BXS5 FXR2 Homo sapiens P51116 32296183
Intra
AP1M1 Q9BXS5 TIFA Homo sapiens Q96CG3 25416956
Intra
AP1M1 Q9BXS5 TIFA Homo sapiens Q96CG3 25416956
Intra
AP1M1 Q9BXS5 TIFA Homo sapiens Q96CG3 32296183
Intra
AP1M1 Q9BXS5 TIFA Homo sapiens Q96CG3 25416956
Intra
AP1M1 Q9BXS5 TIFA Homo sapiens Q96CG3 32296183
Intra
AP1M1 Q9BXS5 TIFA Homo sapiens Q96CG3 16189514
Intra
AP1M1 Q9BXS5 ZBTB43 Homo sapiens O43298 32296183
Intra
AP1M1 Q9BXS5 ZBTB43 Homo sapiens O43298 25416956
Intra
AP1M1 Q9BXS5 ZBTB43 Homo sapiens O43298 32296183
Intra
AP1M1 Q9BXS5 LDOC1 Homo sapiens O95751 32296183
Intra
AP1M1 Q9BXS5 LDOC1 Homo sapiens O95751 16189514
Intra
AP1M1 Q9BXS5 LDOC1 Homo sapiens O95751 32296183
Intra
AP1M1 Q9BXS5 LZTS2 Homo sapiens Q9BRK4 25416956
Intra
AP1M1 Q9BXS5 LZTS2 Homo sapiens Q9BRK4 25416956
Intra
AP1M1 Q9BXS5 SDCBP2 Homo sapiens Q9H190 32296183
Intra
AP1M1 Q9BXS5 SDCBP2 Homo sapiens Q9H190 32296183
Intra
AP1M1 Q9BXS5 SDCBP2 Homo sapiens Q9H190 32296183
Intra
AP1M1 Q9BXS5 ZBTB8A Homo sapiens Q96BR9 32296183
Intra
AP1M1 Q9BXS5 ZBTB8A Homo sapiens Q96BR9 25416956
Intra
AP1M1 Q9BXS5 ZBTB8A Homo sapiens Q96BR9 16189514
Intra
AP1M1 Q9BXS5 ZBTB8A Homo sapiens Q96BR9 25416956
Intra
AP1M1 Q9BXS5 ZBTB8A Homo sapiens Q96BR9 32296183
Intra
AP1M1 Q9BXS5 HOOK2 Homo sapiens Q96ED9 25416956
Intra
AP1M1 Q9BXS5 HOOK2 Homo sapiens Q96ED9 25416956
Intra
AP1M1 Q9BXS5 EFEMP2 Homo sapiens O95967 32296183
Intra
AP1M1 Q9BXS5 EFEMP2 Homo sapiens O95967 32296183
Intra
AP1M1 Q9BXS5 MEA1 Homo sapiens Q16626 32296183
Intra
AP1M1 Q9BXS5 MEA1 Homo sapiens Q16626 32296183
Intra
AP1M1 Q9BXS5 IKZF1 Homo sapiens Q13422 25416956
Intra
AP1M1 Q9BXS5 IKZF1 Homo sapiens Q13422 25416956
Intra
AP1M1 Q9BXS5 ZCCHC17 Homo sapiens Q9NP64 32296183
Intra
AP1M1 Q9BXS5 ZCCHC17 Homo sapiens Q9NP64 32296183
Intra
AP1M1 Q9BXS5 ZCCHC17 Homo sapiens Q9NP64 32296183
Intra
AP1M1 Q9BXS5 MTF1 Homo sapiens Q14872 19060904
Intra
AP1M1 Q9BXS5 MTF1 Homo sapiens Q14872 19060904
Intra
AP1M1 Q9BXS5 RUNDC3A Homo sapiens Q59EK9 25416956
Intra
AP1M1 Q9BXS5 RUNDC3A Homo sapiens Q59EK9 16189514
Intra
AP1M1 Q9BXS5 PAX6 Homo sapiens P26367 32296183
Intra
AP1M1 Q9BXS5 PAX6 Homo sapiens P26367 32296183
Intra
AP1M1 Q9BXS5 RSPH14 Homo sapiens Q9UHP6 32296183
Intra
AP1M1 Q9BXS5 RSPH14 Homo sapiens Q9UHP6 32296183
Intra
AP1M1 Q9BXS5 RSPH14 Homo sapiens Q9UHP6 32296183
Intra
AP1M1 Q9BXS5 EVI5L Homo sapiens Q96CN4 32296183
Intra
AP1M1 Q9BXS5 EVI5L Homo sapiens Q96CN4 32296183
Intra
AP1M1 Q9BXS5 ZNF276 Homo sapiens Q8N554 32296183
Intra
AP1M1 Q9BXS5 ZNF276 Homo sapiens Q8N554 32296183
Intra
AP1M1 Q9BXS5 ARNT2 Homo sapiens Q9HBZ2 32296183
Intra
AP1M1 Q9BXS5 ARNT2 Homo sapiens Q9HBZ2 32296183
Intra
AP1M1 Q9BXS5 PICK1 Homo sapiens Q9NRD5 32296183
Intra
AP1M1 Q9BXS5 PICK1 Homo sapiens Q9NRD5 32296183
Intra
AP1M1 Q9BXS5 PICK1 Homo sapiens Q9NRD5 32296183
Intra
AP1M1 Q9BXS5 LRATD2 Homo sapiens Q96KN1 32296183
Intra
AP1M1 Q9BXS5 LRATD2 Homo sapiens Q96KN1 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mental Retardation, Enteropathy, Deafness, Peripheral Neuropathy, Ichthyosis, And Keratoderma

Mednik Syndrome

Erythrokeratodermia Variabilis 3

MEDNIK

Ekv3

Erythrokeratodermia Variabilis, Kamouraska Type

Mental Retardation, Enteropathy, Deafness, Neuropathy, Ichthyosis, Keratodermia

Intellectual Disability-Enteropathy-Deafness-Peripheral Neuropathy-Ichthyosis-Keratodermia Syndrome

Intellectual Disability-Enteropathy-Hearing Loss-Peripheral Neuropathy-Ichthyosis-Keratodermia Syndrome

Intellectual Disability, Enteropathy, Deafness, Peripheral Neuropathy, Ichthyosis, And Keratoderma

Erythrokeratodermia Variabilis Kamouraska Type

Mental Retardation, Enteropathy, Deafness, Peripheral Neuropathy, Ichthyosis, Keratoderma

Pettigrew Syndrome

PGS

Mrxs5

Mrx59

Mrxs21

X-Linked Intellectual Disability-Dandy-Walker Malformation-Basal Ganglia Disease-Seizures Syndrome

Mental Retardation, X-Linked, Syndromic 5

Mrxsf

Syndromic X-Linked Intellectual Disability 5

Fried Syndrome

Mental Retardation, X-Linked Syndromic 5

Mental Retardation, X-Linked, With Dandy-Walker Malformation, Basal Ganglia Disease, And Seizures

Mental Retardation, X-Linked, Syndromic, Fried Type

Mental Retardation, X-Linked, Syndromic 21

Syndromic X-Linked Mental Retardation 21

Syndromic X-Linked Mental Retardation Fried Type

X-Linked Metal Retardation With Dandy-Walker Malformation, Basal Ganglia Disease, And Seizures

Dandy-Walker Malformation With Intellectual Disability, Basal Ganglia Disease An

Dandy-Walker Malformation With Intellectual Disability, Basal Ganglia Disease And Seizures

X-Linked Syndromic Intellectual Disability 5

X-Linked Intellectual Disability With Dandy-Walker Malformation Basal Ganglia Disease And Seizures

X-Linked Intellectual Disability - Dandy-Walker Malformation - Basal Ganglia Disease - Seizures

X-Linked Intellectual Disability-Hypotonia-Facial Dysmorphism-Aggressive Behavior Syndrome

Mental Retardation, X-Linked Syndromic, Fried Type

Dandy-Walker Malformation With Mental Retardation, Basal Ganglia Disease, And Seizures

Mental Retardation, X-Linked 59

Intermittent Squint

Intermittent Heterotropia

Intermittent Tropia

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus AP1M1 MGD MGI:102776
Macaca mulatta AP1M1 VGNC VGNC:69824
Canis familiaris AP1M1 VGNC VGNC:37954
Felis catus AP1M1 VGNC VGNC:59840
Rattus norvegicus AP1M1 RGD RGD:1307653
Bos taurus AP1M1 VGNC VGNC:25979