NEUROD4 - neuronal differentiation 4 Gene

Homo sapiens

Also known as ATH3; ATH-3; Atoh3; MATH3; MATH-3; bHLHa4

Gene ID: 58158 | Gene type: protein coding

About NEUROD4

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,019,974-55,030,017 (from NCBI)

This gene has 1 transcript (splice variant), 253 orthologues and 15 paralogues. Biased expression in adrenal (RPKM 1.3), brain (RPKM 0.2) and 1 other tissue.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in amacrine cell differentiation; positive regulation of cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including Notch signaling pathway; camera-type eye development; and neurogenesis. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NEUROD4 Products(1)

mRNA	Protein	Name
NM_021191.3	NP_067014.2	neurogenic differentiation factor 4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEUROD4 Protein Structure

HLH

Neuro_bHLH

0
100
200
300
331 a.a.

Protein Preferred Names

Protein Names

neurogenic differentiation factor 4

class A basic helix-loop-helix protein 4

NEUROD4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NEUROD4	Q9HD90	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	NEUROD4	Q9HD90	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cardiac Valvular Dysplasia, X-Linked

Xmvd	X-Linked Cardiac Valvular Dysplasia
CVD1	Filamin A-Related X-Linked Myxomatous Valvular Dysplasia
Flna-Related Valvular Dystrophy	Flna-Related X-Linked Myxomatous Valvular Dysplasia
Valvular Heart Disease, Congenital	Myxomatous Valvular Dystrophy, X-Linked
Congenital Valvular Heart Disease	X-Linked Myxomatous Valvular Dystrophy
CVDPX	Ehlers-Danlos Syndrome, Type V, Formerly
Eds5, Formerly	Dystrophie Valvulaire Associee A Flna
Eds 5	Ehlers-Danlos Syndrome, Type 5
Dystrophie Valvulaire Associée À Flna	Filamin-A-Associated Myxomatous Mitral Valve Disease
Filamin-A-Related Myxomatous Mitral Valve Dystrophy	Congenital Valvular Dysplasia
Cvdx	Ehlers-Danlos Syndrome Type 5

Panhypopituitarism, X-Linked

PHPX	X-Linked Panhypopituitarism
Pituitary Dwarfism Iv	Panhypopituitarism X-Linked
Pituitary Dwarfism Iv, Formerly	Panhypopituitarism - X-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09226	NEUROD4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NEUROD4	VGNC	VGNC:43754
Rattus norvegicus	NEUROD4	RGD	RGD:1310434
Felis catus	NEUROD4	VGNC	VGNC:63784
Mus musculus	NEUROD4	MGD	MGI:108055
Bos taurus	NEUROD4	VGNC	VGNC:32019

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