RHOU - ras homolog family member U Gene

Homo sapiens

Also known as ARHU; G28K; WRCH1; hG28K; CDC42L1

Gene ID: 58480 | Gene type: protein coding

About RHOU

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:228,644,647-228,746,669 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 199 orthologues and 22 paralogues. Ubiquitous expression in brain (RPKM 24.2), small intestine (RPKM 22.4) and 25 other tissues.

Summary

This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity Phosphatase 5 pseudogene) locus.[provided by RefSeq, Mar 2011]

RHOU Products(1)

mRNA	Protein	Name
NM_021205.6	NP_067028.1	rho-related GTP-binding protein RhoU

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14521508	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21834987	GOA
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	21834987	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHOU Protein Structure

Ras

0
100
200
258 a.a.

Protein Preferred Names

Protein Names

rho-related GTP-binding protein RhoU

2310026M05Rik

RHOU Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RHOU	Q7L0Q8	PTK2B	Homo sapiens	Q14289	Y2H	18086875
Intra	RHOU	Q7L0Q8	NCK2	Homo sapiens	O43639	Pull Down	15350535
Intra	RHOU	Q7L0Q8	NCK2	Homo sapiens	O43639	Anti Bait CoIP	15350535

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Myopathy, Centronuclear, 2

Myopathy, Centronuclear, Autosomal Recessive	Autosomal Recessive Centronuclear Myopathy
CNM2	Centronuclear Myopathy 2
Ar-Cnm	Myotubular Myopathy, Autosomal Recessive
Autosomal Recessive Myotubular Myopathy	Centronuclear Myopathy Autosomal Recessive
Myopathy, Centronuclear, Type 2

Toxic Megacolon

Megacolon, Toxic	Toxic Dilatation Of Colon
Toxic Functional Megacolon

Clostridium Difficile Colitis

Pseudomembranous Colitis	Colitis Pseudomembranous
Enterocolitis, Pseudomembranous	Pseudomembranous Enterocolitis
Clostridium Difficile Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11959	RHOU Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RHOU	VGNC	VGNC:33955
Rattus norvegicus	RHOU	RGD	RGD:1596918
Macaca mulatta	RHOU	VGNC	VGNC:76756
Canis familiaris	RHOU	VGNC	VGNC:45565
Mus musculus	RHOU	MGD	MGI:1916831

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