ZNF77 - zinc finger protein 77 Gene

Homo sapiens

Also known as pT1

Gene ID: 58492 | Gene type: protein coding

About ZNF77

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:2,933,218-2,950,625 (from NCBI)

This gene has 2 transcripts (splice variants), 154 orthologues and 62 paralogues. Ubiquitous expression in thyroid (RPKM 1.9), testis (RPKM 1.7) and 25 other tissues.

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZNF77 Products(1)

mRNA	Protein	Name
NM_021217.3	NP_067040.1	zinc finger protein 77

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF77 Protein Structure

KRAB

zf-C2H2_4

zf-H2C2_2

0
100
200
300
400
500
545 a.a.

Protein Preferred Names

Protein Names

zinc finger protein 77

ZNFpT1

ZNF77 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZNF77	Q15935	MBD3L1	Homo sapiens	Q8WWY6	Y2H Prey Pooling	32296183
Intra	ZNF77	Q15935	MBD3L1	Homo sapiens	Q8WWY6	Validated Y2H	32296183
Intra	ZNF77	Q15935	MBD3L1	Homo sapiens	Q8WWY6	Y2H Array	32296183
Intra	ZNF77	Q15935	RSPO4	Homo sapiens	Q2I0M5	Y2H Prey Pooling	32296183
Intra	ZNF77	Q15935	RSPO4	Homo sapiens	Q2I0M5	Y2H Array	32296183
Intra	ZNF77	Q15935	RSPO4	Homo sapiens	Q2I0M5	Validated Y2H	32296183
Intra	ZNF77	Q15935	NICN1	Homo sapiens	Q9BSH3	Y2H Array	32296183
Intra	ZNF77	Q15935	NICN1	Homo sapiens	Q9BSH3	Validated Y2H	32296183
Intra	ZNF77	Q15935	NICN1	Homo sapiens	Q9BSH3	Y2H Prey Pooling	32296183
Intra	ZNF77	Q15935	FTO	Homo sapiens	Q9C0B1-2	Validated Y2H	32296183
Intra	ZNF77	Q15935	FTO	Homo sapiens	Q9C0B1-2	Y2H Array	32296183
Intra	ZNF77	Q15935	FTO	Homo sapiens	Q9C0B1-2	Y2H Prey Pooling	32296183
Intra	ZNF77	Q15935	RUSC1	Homo sapiens	Q9BVN2	Y2H Array	32296183
Intra	ZNF77	Q15935	RUSC1	Homo sapiens	Q9BVN2	Y2H Prey Pooling	32296183
Intra	ZNF77	Q15935	RUSC1	Homo sapiens	Q9BVN2	Validated Y2H	32296183
Intra	ZNF77	Q15935	PRDX3	Homo sapiens	P30048	Y2H Prey Pooling	32296183
Intra	ZNF77	Q15935	PRDX3	Homo sapiens	P30048	Y2H Array	32296183
Intra	ZNF77	Q15935	METTL27	Homo sapiens	Q8N6F8	Validated Y2H	32296183
Intra	ZNF77	Q15935	METTL27	Homo sapiens	Q8N6F8	Y2H Array	32296183
Intra	ZNF77	Q15935	METTL27	Homo sapiens	Q8N6F8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Tuberculous Epididymitis

Tuberculosis Of Epididymis

Anorectal Stricture

Stenosis Of Rectum And Anus

Anorectal Malformations

Bone Squamous Cell Carcinoma

Bladder Lateral Wall Cancer

Lateral Wall Of Bladder

Malignant Neoplasm Of Lateral Wall Of Urinary Bladder

Essential Thrombocythemia

Essential Thrombocytosis	Familial Thrombocytosis
Hemorrhagic Thrombocythemia	Hereditary Thrombocythemia
Primary Thrombocytosis	Idiopathic Thrombocythemia
Primary Thrombocythemia	Thrombocythemia, Essential
Essential Thrombocythaemia	Et
Familial Thrombocythemia	Thrombocythemia Essential

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16175	ZNF77 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZNF77	RGD	RGD:6497573
Macaca mulatta	ZNF77	VGNC	VGNC:78906

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