OSTC - oligosaccharyltransferase complex non-catalytic subunit Gene

Homo sapiens

Also known as DC2

Gene ID: 58505 | Gene type: protein coding

About OSTC

Cytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:108,650,599-108,667,820 (from NCBI)

This gene has 5 transcripts (splice variants) and 230 orthologues. Ubiquitous expression in thyroid (RPKM 57.1), endometrium (RPKM 49.2) and 25 other tissues.

Summary

Predicted to contribute to dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in protein N-linked glycosylation via asparagine. Part of oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

OSTC Products(3)

mRNA	Protein	Name
NM_001267817.2	NP_001254746.1	oligosaccharyltransferase complex subunit OSTC isoform 2
NM_001267818.2	NP_001254747.1	oligosaccharyltransferase complex subunit OSTC isoform 3
NM_021227.4	NP_067050.1	oligosaccharyltransferase complex subunit OSTC isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of oligosaccharyltransferase complex	IDA IDA: Inferred from direct assay	15835887	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OSTC Protein Structure

OST3_OST6

0
100
149 a.a.

Protein Preferred Names

Protein Names

oligosaccharyltransferase complex subunit OSTC

hydrophobic protein HSF-28

Related Diseases

Diseases

Alias

Corticosteroid Allergy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09855	OSTC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	OSTC	MGD	MGI:1913607
Canis familiaris	OSTC	VGNC	VGNC:44170
Felis catus	OSTC	VGNC	VGNC:107382
Macaca mulatta	OSTC	VGNC	VGNC:107187
Bos taurus	OSTC	VGNC	VGNC:32478
Rattus norvegicus	OSTC	RGD	RGD:1560708

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