SINHCAF - SIN3-HDAC complex associated factor Gene

Homo sapiens

Also known as L4; TERA; FAM60A; C12orf14

Gene ID: 58516 | Gene type: protein coding

About SINHCAF

Cytogenetic location: 12p11.21 Genomic coordinates (GRCh38): 12:31,280,584-31,326,150 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele and 270 orthologues. Ubiquitous expression in endometrium (RPKM 24.9), lymph node (RPKM 18.1) and 25 other tissues.

Summary

Involved in negative regulation of cell migration. Part of Sin3 complex. [provided by Alliance of Genome Resources, Apr 2022]

SINHCAF Products(3)

mRNA	Protein	Name
NM_001135811.2	NP_001129283.1	SIN3-HDAC complex-associated factor
NM_001135812.2	NP_001129284.1	SIN3-HDAC complex-associated factor
NM_021238.3	NP_067061.1	SIN3-HDAC complex-associated factor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23752268	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	22984288	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Sin3-type complex	IDA IDA: Inferred from direct assay	22984288	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SINHCAF Protein Structure

FAM60A

0
100
200
221 a.a.

Protein Preferred Names

Protein Names

SIN3-HDAC complex-associated factor

family with sequence similarity 60 member A

SINHCAF Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SINHCAF	Q9NP50	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	33961781
Intra	SINHCAF	Q9NP50	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	28514442
Intra	SINHCAF	Q9NP50	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	23752268

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SINHCAF Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700391	SINHCAF Protein, Human (GST)	Q9NP50-1 (M1-W221)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12927	SINHCAF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SINHCAF	RGD	RGD:1595037
Macaca mulatta	SINHCAF	VGNC	VGNC:103865
Canis familiaris	SINHCAF	VGNC	VGNC:49879
Bos taurus	SINHCAF	VGNC	VGNC:34626
Mus musculus	SINHCAF	MGD	MGI:1929091
Others	SINHCAF	NCBI

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