MPP4 - MAGUK p55 scaffold protein 4 Gene

Homo sapiens

Also known as DLG6; ALS2CR5

Gene ID: 58538 | Gene type: protein coding

About MPP4

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:201,644,874-201,698,644 (from NCBI)

This gene has 12 transcripts (splice variants), 277 orthologues and 7 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) protein family, with an N-terminal PDZ domain, a central Src homology 3 region (SH3), and a C-terminal guanylate kinase-like (GUK) domain. The protein is localized to the outer limiting membrane in the retina, and is thought to function in photoreceptor polarity and the organization of specialized intercellular junctions. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

MPP4 Products(1)

mRNA	Protein	Name
NM_033066.3	NP_149055.2	MAGUK p55 subfamily member 4

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15914641	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in adherens junction	IDA IDA: Inferred from direct assay	15914641	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	15914641	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MPP4 Protein Structure

L27

PDZ

SH3_1

Guanylate_kin

0
100
200
300
400
500
600
637 a.a.

Protein Preferred Names

Protein Names

MAGUK p55 subfamily member 4

amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein

MPP4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MPP4	Q96JB8	CRB1	Homo sapiens	P82279	Anti Bait CoIP	15914641
Intra	MPP4	Q96JB8	CRB1	Homo sapiens	P82279	Anti Tag CoIP	15914641

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Nanophthalmos

Nanophthalmia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08625	MPP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MPP4	VGNC	VGNC:74734
Mus musculus	MPP4	MGD	MGI:2386681
Rattus norvegicus	MPP4	RGD	RGD:620016
Bos taurus	MPP4	VGNC	VGNC:106825
Canis familiaris	MPP4	VGNC	VGNC:43345
Felis catus	MPP4	VGNC	VGNC:97516

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