Crhr1 - corticotropin releasing hormone receptor 1 Gene

Rattus norvegicus

Also known as CRF1; CRF-R; CRFR1; CRH-R; CRF-R1; CRFR-1; CRH-R1; CRF-R-1; CRH-R 1; CRH-R-1

Gene ID: 58959 | Gene type: protein coding

About Crhr1

Primary_assembly 10: 89,040,203-89,083,481 forward strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 239 orthologues, 42 paralogues and is associated with 29 phenotypes. Restricted expression toward (RPKM 31.6).

Summary

This gene encodes a member of the G-protein coupled receptor family. The encoded protein is a receptor for corticotropin-releasing factor (CRH) and urocortin (UCN). The interaction of this protein with CRH and UCN triggers G-protein coupled signaling. This protein plays a pivotal role in mediating the CRH-elicited effects in depression and anxiety. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Crhr1 Products(2)

mRNA	Protein	Name
NM_001301812.2	NP_001288741.2	corticotropin-releasing factor receptor 1 isoform 2 precursor
NM_030999.5	NP_112261.2	corticotropin-releasing factor receptor 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	11902119	RGD
enables G-protein alpha-subunit binding	IPI IPI: Inferred from physical interaction	20548297	RGD
enables corticotropin-releasing hormone binding	IDA IDA: Inferred from direct assay	12942143	RGD
enables corticotropin-releasing hormone receptor activity	IDA IDA: Inferred from direct assay	12942143	RGD
enables peptide binding	IDA IDA: Inferred from direct assay	15049707	RGD
enables peptide binding	IPI IPI: Inferred from physical interaction	15932935	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	24290358	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	20548297	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	15932935	RGD
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	11784785	RGD
involved in behavioral response to cocaine	IMP IMP: Inferred from mutant phenotype	21813699	RGD
involved in behavioral response to pain	IMP IMP: Inferred from mutant phenotype	17550594	RGD
involved in epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	20551459	RGD
involved in feeding behavior	IMP IMP: Inferred from mutant phenotype	12559107	RGD
involved in hypothalamus development	IEP IEP: Inferred from expression pattern	20002962	RGD
involved in locomotory exploration behavior	IMP IMP: Inferred from mutant phenotype	9299637	RGD
involved in long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	19376201	RGD
involved in memory	IMP IMP: Inferred from mutant phenotype	15932935	RGD
involved in negative regulation of epinephrine secretion	IMP IMP: Inferred from mutant phenotype	12606499	RGD
involved in negative regulation of feeding behavior	IMP IMP: Inferred from mutant phenotype	14512273	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	11784785	RGD
involved in neuropeptide signaling pathway	IDA IDA: Inferred from direct assay	11784785	RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	15932935	RGD
involved in positive regulation of cAMP/PKA signal transduction	IMP IMP: Inferred from mutant phenotype	20682782	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	16513211	RGD
involved in positive regulation of mast cell degranulation	IMP IMP: Inferred from mutant phenotype	18209484	RGD
involved in regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	17079348	RGD
involved in response to electrical stimulus	IMP IMP: Inferred from mutant phenotype	17015825	RGD
involved in response to hypoxia	IMP IMP: Inferred from mutant phenotype	16099461	RGD
involved in response to immobilization stress	IEP IEP: Inferred from expression pattern	21664419	RGD
involved in visual learning	IMP IMP: Inferred from mutant phenotype	15932935	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	12911751	RGD
located in dendrite	IDA IDA: Inferred from direct assay	12911751	RGD
NOT located in dendritic spine	IDA IDA: Inferred from direct assay	12911751	RGD
located in multivesicular body	IDA IDA: Inferred from direct assay	12911751	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12911751	RGD
located in trans-Golgi network	IDA IDA: Inferred from direct assay	12911751	RGD
located in vesicle	IDA IDA: Inferred from direct assay	12911751	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

corticotropin-releasing factor receptor 1

corticotrophin releasing hormone receptor 1

corticotropin releasing hormone 1

Crhr1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Crhr1	P35353	Ucn	Rattus norvegicus	P55090	Crosslink	24290358

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103377	Antalarmin hydrochloride	Antagonist	99.87%	Unkown
HY-124475	Antalarmin	Antagonist	98.01%	Unkown
HY-12131	DMP 696	Antagonist	99.03%	Unkown
HY-RS03168	CRHR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03169	Crhr1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03170	Crhr1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-139035	CRHR1 antagonist 1	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Crhr1	NCBI	NCBI:1394

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