Smpd3 - sphingomyelin phosphodiesterase 3, neutral Gene

Mus musculus

Also known as fro; nSMase2; 4631433G07Rik

Gene ID: 58994 | Gene type: protein coding

About Smpd3

Summary

Enables identical protein binding activity; neutral sphingomyelin phosphodiesterase activity; and phospholipid binding activity. Involved in sphingomyelin metabolic process. Acts upstream of or within several processes, including animal organ development; Enzyme linked receptor protein signaling pathway; and sphingolipid metabolic process. Located in Golgi cis cisterna and plasma membrane. Is expressed in several structures, including alimentary system; limb; nervous system; sensory organ; and skeleton. Used to study hypopituitarism; osteogenesis imperfecta; osteogenesis imperfecta type 2; and osteogenesis imperfecta type 3. Orthologous to human SMPD3 (sphingomyelin phosphodiesterase 3). [provided by Alliance of Genome Resources, Apr 2022]

Smpd3 Products(1)

mRNA	Protein	Name
NM_021491.4	NP_067466.1	sphingomyelin phosphodiesterase 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25287744	MGI
enables neutral sphingomyelin phosphodiesterase activity	IDA IDA: Inferred from direct assay	16025116	MGI
enables phosphatidic acid binding	IDA IDA: Inferred from direct assay	21550973	MGI
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	21550973	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20080539	MGI
enables sphingomyelin phosphodiesterase activity	IDA IDA: Inferred from direct assay	10823942	MGI
enables sphingomyelin phosphodiesterase activity	IMP IMP: Inferred from mutant phenotype	15764706	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within BMP signaling pathway	IDA IDA: Inferred from direct assay	24505141	MGI
acts upstream of or within DNA biosynthetic process	IMP IMP: Inferred from mutant phenotype	23651497	MGI
acts upstream of or within G1 to G0 transition	IMP IMP: Inferred from mutant phenotype	23046545	MGI
acts upstream of or within bone development	IMP IMP: Inferred from mutant phenotype	27325675	MGI
acts upstream of or within bone growth	IMP IMP: Inferred from mutant phenotype	17626887	MGI
acts upstream of or within bone mineralization	IDA IDA: Inferred from direct assay	21788370	MGI
acts upstream of or within bone mineralization	IMP IMP: Inferred from mutant phenotype	21788370	MGI
acts upstream of or within cartilage development	IDA IDA: Inferred from direct assay	27325675	MGI
acts upstream of or within cartilage development	IMP IMP: Inferred from mutant phenotype	17591962	MGI
acts upstream of or within cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	23651497	MGI
acts upstream of or within cellular response to magnesium ion	IDA IDA: Inferred from direct assay	23973266	MGI
acts upstream of or within cellular response to oxidised low-density lipoprotein particle stimulus	IMP IMP: Inferred from mutant phenotype	20352118	MGI
acts upstream of or within cellular response to peptide	IMP IMP: Inferred from mutant phenotype	27325675	MGI
acts upstream of or within cellular response to reactive oxygen species	IMP IMP: Inferred from mutant phenotype	17561096	MGI
acts upstream of or within cellular response to redox state	IMP IMP: Inferred from mutant phenotype	25287744	MGI
acts upstream of or within cellular response to tumor necrosis factor	IMP IMP: Inferred from mutant phenotype	16025116	MGI
acts upstream of or within ceramide metabolic process	IMP IMP: Inferred from mutant phenotype	22383528	MGI
acts upstream of or within chondrocyte development	IMP IMP: Inferred from mutant phenotype	17591962	MGI
acts upstream of or within chondrocyte development involved in endochondral bone morphogenesis	IMP IMP: Inferred from mutant phenotype	21788370	MGI
acts upstream of or within collagen metabolic process	IMP IMP: Inferred from mutant phenotype	22910579	MGI
acts upstream of or within dentinogenesis	IMP IMP: Inferred from mutant phenotype	16025116	MGI
acts upstream of or within endochondral ossification	IMP IMP: Inferred from mutant phenotype	17591962	MGI
acts upstream of or within extracellular matrix assembly	IMP IMP: Inferred from mutant phenotype	22910579	MGI
acts upstream of or within hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	24029230	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	22945695	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	22945695	MGI
acts upstream of or within mitotic nuclear division	IMP IMP: Inferred from mutant phenotype	20352118	MGI
acts upstream of or within multicellular organism growth	IDA IDA: Inferred from direct assay	24585429	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	24585429	MGI
acts upstream of or within negative regulation of hyaluronan biosynthetic process	IMP IMP: Inferred from mutant phenotype	22383528	MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	24505141	MGI
acts upstream of or within ossification	IMP IMP: Inferred from mutant phenotype	16025116	MGI
acts upstream of or within peptide hormone secretion	IMP IMP: Inferred from mutant phenotype	15764706	MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23651497	MGI
acts upstream of or within polysaccharide transport	IMP IMP: Inferred from mutant phenotype	22383528	MGI
acts upstream of or within positive regulation of mitotic nuclear division	IGI IGI: Inferred from genetic interaction	23651497	MGI
acts upstream of or within positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	17561096	MGI
acts upstream of or within regulation of cartilage development	IMP IMP: Inferred from mutant phenotype	24505141	MGI
acts upstream of or within regulation of hyaluronan biosynthetic process	IMP IMP: Inferred from mutant phenotype	22383528	MGI
acts upstream of or within regulation of leukocyte migration	IMP IMP: Inferred from mutant phenotype	28377412	MGI
acts upstream of or within regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	22383528	MGI
acts upstream of or within respiratory system development	IMP IMP: Inferred from mutant phenotype	22945695	MGI
acts upstream of or within signal transduction	IMP IMP: Inferred from mutant phenotype	17561096	MGI
acts upstream of or within skeletal system development	IDA IDA: Inferred from direct assay	24585429	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	17591962	MGI
acts upstream of or within sphingolipid mediated signaling pathway	IDA IDA: Inferred from direct assay	23651497	MGI
acts upstream of or within sphingolipid metabolic process	IMP IMP: Inferred from mutant phenotype	22945695	MGI
acts upstream of or within sphingomyelin catabolic process	IMP IMP: Inferred from mutant phenotype	23973266	MGI
acts upstream of or within sphingomyelin metabolic process	IDA IDA: Inferred from direct assay	10823942	MGI
involved in sphingomyelin metabolic process	IDA IDA: Inferred from direct assay	21550973	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	10823942	MGI
located in Golgi cis cisterna	IDA IDA: Inferred from direct assay	15764706	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	21550973	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sphingomyelin phosphodiesterase 3

nSMase-2	neutral sphingomyelinase 2
neutral sphingomyelinase II

Smpd3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Smpd3	Q9JJY3	HSPD1	Homo sapiens	P10809	Anti Bait CoIP	23840630
Cross	Smpd3	Q9JJY3	HSPD1	Homo sapiens	P10809	PLA	23840630
Cross	Smpd3	Q9JJY3	EED	Homo sapiens	O75530	Y2H	20080539

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13449	SMPD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Smpd3	NCBI	NCBI:55512

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