Tgfb1 - transforming growth factor, beta 1 Gene

Rattus norvegicus

Also known as Tgfb

Gene ID: 59086 | Gene type: protein coding

About Tgfb1

Primary_assembly 1: 81,196,532-81,212,847 forward strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 210 orthologues, 31 paralogues and is associated with 174 phenotypes. Biased expression in Spleen (RPKM 118.3), Thymus (RPKM 42.1) and 6 other tissues.

Summary

Enables identical protein binding activity and protein N-terminus binding activity. Involved in several processes, including animal organ development; cellular response to hormone stimulus; and regulation of epithelial cell proliferation. Acts upstream of or within positive regulation of smooth muscle cell differentiation. Located in several cellular components, including cell surface; neuronal cell body; and secretory granule. Used to study chronic obstructive pulmonary disease; familial hyperlipidemia; hypertension; proteinuria; and pulmonary fibrosis. Biomarker of several diseases, including allergic rhinitis; artery disease (multiple); cerebrovascular disease (multiple); gastrointestinal system Cancer (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Camurati-Engelmann disease; aphthous stomatitis; artery disease (multiple); and lung disease (multiple). Orthologous to human TGFB1 (transforming growth factor beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Tgfb1 Products(1)

mRNA	Protein	Name
NM_021578.2	NP_067589.1	transforming growth factor beta-1 proprotein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	18406405	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	18406405	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in animal organ regeneration	IMP IMP: Inferred from mutant phenotype	9699514	RGD
involved in cellular response to acetaldehyde	IEP IEP: Inferred from expression pattern	12223100	RGD
involved in cellular response to dexamethasone stimulus	IDA IDA: Inferred from direct assay	17537984	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	32065356	RGD
involved in cellular response to insulin-like growth factor stimulus	IEP IEP: Inferred from expression pattern	25335926	RGD
involved in cellular response to ionizing radiation	IEP IEP: Inferred from expression pattern	25600523	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19012730	RGD
involved in defense response to fungus	IDA IDA: Inferred from direct assay	16272332	RGD
involved in digestive tract development	IEP IEP: Inferred from expression pattern	12815632	RGD
involved in epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	10504497	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	15927076	RGD
involved in frontal suture morphogenesis	IEP IEP: Inferred from expression pattern	12416537	RGD
involved in inner ear development	IEP IEP: Inferred from expression pattern	16479080	RGD
involved in liver regeneration	IEP IEP: Inferred from expression pattern	25862490	RGD
involved in morphogenesis of a branching structure	IDA IDA: Inferred from direct assay	15192047	RGD
involved in myelination	IMP IMP: Inferred from mutant phenotype	14648590	RGD
involved in negative regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	15192047	RGD
involved in negative regulation of neuroblast proliferation	IDA IDA: Inferred from direct assay	16177030	RGD
involved in negative regulation of phagocytosis	IDA IDA: Inferred from direct assay	16272332	RGD
involved in negative regulation of release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	12876066	RGD
involved in odontogenesis of dentin-containing tooth	IEP IEP: Inferred from expression pattern	29175126	RGD
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	15781474	RGD
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	16157589	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16532270	RGD
involved in positive regulation of branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	17537984	RGD
involved in positive regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	26923362	RGD
involved in positive regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	15192047	RGD
involved in positive regulation of exit from mitosis	IDA IDA: Inferred from direct assay	16177030	RGD
involved in positive regulation of mononuclear cell migration	IMP IMP: Inferred from mutant phenotype	26923362	RGD
acts upstream of or within positive regulation of smooth muscle cell differentiation	IDA IDA: Inferred from direct assay	8616889	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	23393573	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	15746252	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	29399060	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	18587447	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	17213961	RGD
involved in response to immobilization stress	IEP IEP: Inferred from expression pattern	25641164	RGD
involved in response to laminar fluid shear stress	IEP IEP: Inferred from expression pattern	16217485	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	15746252	RGD
involved in response to salt	IEP IEP: Inferred from expression pattern	23249995	RGD
involved in response to vitamin D	IEP IEP: Inferred from expression pattern	11956143	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	11597910	RGD
involved in transforming growth factor beta receptor signaling pathway	IEP IEP: Inferred from expression pattern	33360052	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	15214860	RGD
located in cell surface	IDA IDA: Inferred from direct assay	10487979	RGD
located in collagen-containing extracellular matrix	IDA IDA: Inferred from direct assay	24224514	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	16837651	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15214860	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	15214860	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tgfb1 Protein Structure

TGFb_propeptide

TGF_beta_TGFB1

0
100
200
300
390 a.a.

Protein Preferred Names

Protein Names

transforming growth factor beta-1 proprotein

TGF-beta-1

Recombinant Tgfb1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73615	Latent TGF beta 1/TGFB1 Protein, Rat (HEK293, His)	P17246 (L30-S390)	≥95%
HY-P73615A	Latent TGF beta 1/TGFB1 Protein, Rat (HEK293, C-His)	P17246 (L30-S390)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990009	Nisevokitug	Inhibitor	97.00%	Phase 3
HY-P99305	Metelimumab	Inhibitor	98.98%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147195	QH536	Inhibitor	/	Unkown
HY-N10760	2a,3a,23-Trihydroxyurs-12,20(30)-dien-28-oic acid		/	Unkown
HY-RS14435	TGFB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14436	Tgfb1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14437	Tgfb1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14438	TGFB1I1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W764758	3-OH-Kynurenamine dihydroiodide	Activator	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99606	Cirevetmab	Inhibitor	/	Unkown
HY-P990517	Anti-TGFb1 Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tgfb1	NCBI	NCBI:7040
Canis familiaris	Tgfb1	NCBI	NCBI:403998
Macaca fascicularis	Tgfb1	NCBI	NCBI:102129546
Mus musculus	Tgfb1	NCBI	NCBI:21803
Susscrofa domestica	Tgfb1	NCBI
Macaca mulatta	Tgfb1	NCBI	NCBI:106992315

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