2. Gene
  3. Tgfb1 - transforming growth factor, beta 1 Gene

Tgfb1 - transforming growth factor, beta 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Tgfb

Gene ID: 59086 | Gene type: protein coding

About Tgfb1

Primary_assembly 1: 81,196,532-81,212,847 forward strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 210 orthologues, 31 paralogues and is associated with 174 phenotypes. Biased expression in Spleen (RPKM 118.3), Thymus (RPKM 42.1) and 6 other tissues.

Summary

Enables identical protein binding activity and protein N-terminus binding activity. Involved in several processes, including animal organ development; cellular response to hormone stimulus; and regulation of epithelial cell proliferation. Acts upstream of or within positive regulation of smooth muscle cell differentiation. Located in several cellular components, including cell surface; neuronal cell body; and secretory granule. Used to study chronic obstructive pulmonary disease; familial hyperlipidemia; hypertension; proteinuria; and pulmonary fibrosis. Biomarker of several diseases, including allergic rhinitis; artery disease (multiple); cerebrovascular disease (multiple); gastrointestinal system Cancer (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Camurati-Engelmann disease; aphthous stomatitis; artery disease (multiple); and lung disease (multiple). Orthologous to human TGFB1 (transforming growth factor beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Tgfb1 Products(1)

mRNA Protein Name
NM_021578.2 NP_067589.1 transforming growth factor beta-1 proprotein precursor

Tgfb1 Protein Structure

TGFb_propeptide

TGFb_propeptide: pfam00688 (29 - 260)

TGF_beta_TGFB1

TGF_beta_TGFB1: cd19384 (291 - 389)

  • 0
  • 100
  • 200
  • 300
  • 390 a.a.
Protein Preferred Names Protein Names

transforming growth factor beta-1 proprotein

TGF-beta-1

Recombinant Tgfb1 Proteins

Cat. No. Product Name Accession Purity
HY-P73615 Latent TGF beta 1/TGFB1 Protein, Rat (HEK293, His) P17246 (L30-S390) ≥95%
HY-P73615A Latent TGF beta 1/TGFB1 Protein, Rat (HEK293, C-His) P17246 (L30-S390) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P990009 Nisevokitug Inhibitor / Phase 3
HY-P99305 Metelimumab Inhibitor ≥95.0% Phase 2
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-147195 QH536 Inhibitor / Unkown
HY-N10760 2a,3a,23-Trihydroxyurs-12,20(30)-dien-28-oic acid / Unkown
HY-RS14435 TGFB1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14436 Tgfb1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14437 Tgfb1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14438 TGFB1I1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W764758 3-OH-Kynurenamine dihydroiodide Activator / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99606 Cirevetmab Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tgfb1 NCBI NCBI:7040
Canis familiaris Tgfb1 NCBI NCBI:403998
Macaca fascicularis Tgfb1 NCBI NCBI:102129546
Mus musculus Tgfb1 NCBI NCBI:21803
Susscrofa domestica Tgfb1 NCBI
Macaca mulatta Tgfb1 NCBI NCBI:106992315