2. Metabolic Enzyme/Protease
  3. HMG-CoA Reductase (HMGCR)
  4. QH536

QH536 (Compound 29) is a potent HMGCR degrader with an EC50 of 0.22 μM. QH536 has no side-effect of inducing cholesterol accumulation in cells. QH536 shows anti-inflammatory and can be used for cardiovascular disease and nonalcoholic steatohepatitis research.

For research use only. We do not sell to patients.

QH536 Chemical Structure

QH536 Chemical Structure

CAS No. : 2754254-07-2

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QH536 Related Antibodies

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Description

QH536 (Compound 29) is a potent HMGCR degrader with an EC50 of 0.22 μM. QH536 has no side-effect of inducing cholesterol accumulation in cells. QH536 shows anti-inflammatory and can be used for cardiovascular disease and nonalcoholic steatohepatitis research[1].

IC50 & Target

IC50: 0.22 μM (HMGCR)[1]
Molecular Weight

535.76

Formula

C33H49N3O3
CAS No.
SMILES

C[C@@](C1=CC2)(CC(C=NN3C(C)=O)=C3C(C)1C)[C@](CC4)([H])[C@]2([H])[C@@](CC[C@]5([H])[C@H](C)CCC(N6CCOCC6)=O)([H])[C@]45C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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QH536 Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

QH5362754254-07-2QH 536QH-536HMG-CoA Reductase (HMGCR)LX-2cholesterolRAW264.7NASHnonalcoholic steatohepatitisα-SMACOL1A1TIMP1TGFb1TNF-aIL-6IL-1bCVDcardiovascular diseaseInhibitorinhibitorinhibit

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