RARRES1 - retinoic acid receptor responder 1 Gene

Homo sapiens

Also known as LXNL; TIG1; PERG-1

Gene ID: 5918 | Gene type: protein coding

About RARRES1

Cytogenetic location: 3q25.32 Genomic coordinates (GRCh38): 3:158,696,892-158,732,457 (from NCBI)

This gene has 5 transcripts (splice variants), 118 orthologues and 1 paralogue. Broad expression in appendix (RPKM 33.7), urinary bladder (RPKM 25.5) and 17 other tissues.

Summary

This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate Cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

RARRES1 Products(2)

mRNA	Protein	Name
NM_002888.4	NP_002879.2	retinoic acid receptor responder protein 1 isoform 2 precursor
NM_206963.2	NP_996846.1	retinoic acid receptor responder protein 1 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21303978	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RARRES1 Protein Structure

Latexin

0
100
200
294 a.a.

Protein Preferred Names

Protein Names

retinoic acid receptor responder protein 1

RAR-responsive protein TIG1

RARRES1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RARRES1	P49788	SPINK2	Homo sapiens	P20155	Anti Bait CoIP	31886233

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Neurofibroma

Neurofibromas	Neurofibromatoses
Nerve Sheath Tumors

Pinguecula

Conjunctival Degeneration

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11674	RARRES1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RARRES1	RGD	RGD:1309509
Bos taurus	RARRES1	VGNC	VGNC:33731
Canis familiaris	RARRES1	VGNC	VGNC:45354
Mus musculus	RARRES1	MGD	MGI:1924461
Macaca mulatta	RARRES1	VGNC	VGNC:84065

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