PLAAT4 - phospholipase A and acyltransferase 4 Gene

Homo sapiens

Also known as RIG1; TIG3; HRSL4; HRASLS4; PLAAT-4; RARRES3; PLA1/2-3

Gene ID: 5920 | Gene type: protein coding

About PLAAT4

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:63,536,808-63,546,458 (from NCBI)

This gene has 5 transcripts (splice variants), 73 orthologues and 7 paralogues. Ubiquitous expression in small intestine (RPKM 43.2), duodenum (RPKM 36.6) and 24 other tissues.

Summary

Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear Receptor Proteins that are members of the steroid and Thyroid Hormone Receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]

PLAAT4 Products(1)

mRNA	Protein	Name
NM_004585.5	NP_004576.2	phospholipase A and acyltransferase 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables N-acyltransferase activity	IDA IDA: Inferred from direct assay	22825852	GOA
enables phospholipase A1 activity	IDA IDA: Inferred from direct assay	22825852	GOA
enables phospholipase A2 activity	IDA IDA: Inferred from direct assay	20100577	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17762858	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in N-acylphosphatidylethanolamine metabolic process	IDA IDA: Inferred from direct assay	22825852	GOA
involved in phospholipid metabolic process	IDA IDA: Inferred from direct assay	20100577	GOA
involved in positive regulation of keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	17762858	GOA
involved in positive regulation of protein-glutamine gamma-glutamyltransferase activity	IMP IMP: Inferred from mutant phenotype	17762858	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	17762858	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLAAT4 Protein Structure

LRAT

0
100
164 a.a.

Protein Preferred Names

Protein Names

phospholipase A and acyltransferase 4

HRAS-like suppressor 4

PLAAT4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PLAAT4	Q9UL19	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	25416956
Intra	PLAAT4	Q9UL19	SGTA	Homo sapiens	O43765	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Exocervical Carcinoma

Carcinoma Of Exocervix

Carcinoma Of The Exocervix

Poland Syndrome

Poland Anomaly	Poland Sequence
Poland Syndactyly	Poland'S Syndrome
Poland'S Anomaly	Poland'S Syndactyly
Acro-Pectoro-Renal Field Defect	Brachydactyly, Absent Pectoral Muscles And Agenesis/Hypoplasia Of Kidneys
Unilateral Defect Of Pectoralis Muscle And Syndactyly Of The Hand	Unilateral Defect Of Pectoralis Major And Syndactyly Of The Hand

Psoriasis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10639	PLAAT4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Name
Email *

	Sorry, but the email address you supplied was invalid.