CACNG8 - calcium voltage-gated channel auxiliary subunit gamma 8 Gene

Homo sapiens

Gene ID: 59283 | Gene type: protein coding

About CACNG8

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:53,962,937-53,990,215 (from NCBI)

This gene has 1 transcript (splice variant), 242 orthologues and 5 paralogues. Restricted expression toward brain (RPKM 9.1).

Summary

The protein encoded by this gene is a type I transmembrane AMPA Receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a Calcium Channel gamma subunit. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon. [provided by RefSeq, Dec 2010]

CACNG8 Products(1)

mRNA	Protein	Name
NM_031895.6	NP_114101.4	voltage-dependent calcium channel gamma-8 subunit

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of AMPA receptor activity	IDA IDA: Inferred from direct assay	20805473	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CACNG8 Protein Structure

PMP22_Claudin

0
100
200
300
400
425 a.a.

Protein Preferred Names

Protein Names

voltage-dependent calcium channel gamma-8 subunit

TARP gamma-8

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 32

RP32	Retinitis Pigmentosa-32

Antisocial Personality Disorder

Dissocial Personality Disorder	Asocial Personality
Psychopath.Personality	Psychopathic Personality
Psychopathic Personality Disorder	Sociopathic Personality

Retinitis Pigmentosa 38

RP38	Rod-Cone Dystrophy, Childhood-Onset
Retinitis Pigmentosa, Type 38

Retinitis Pigmentosa 25

RP25	Retinitis Pigmentosa-25
Retinitis Pigmentosa, Type 25

Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia	Arvc
Arvd	Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Arvc Cardiomyopathy	Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia
Arvd/C	Right Ventricular Dysplasia, Arrhythmogenic
Ventricular Dysplasia, Right, Arrhythmogenic	Cardiomyopathy, Ventricular, Right, Arrhythmogenic
Dysplasia, Arrhythmogenic Right Ventricular

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01815	CACNG8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CACNG8	VGNC	VGNC:108485
Mus musculus	CACNG8	MGD	MGI:1932376
Canis familiaris	CACNG8	VGNC	VGNC:38652
Rattus norvegicus	CACNG8	RGD	RGD:628808
Bos taurus	CACNG8	VGNC	VGNC:52183

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