REG1B - regenerating family member 1 beta Gene

Homo sapiens

Also known as REGH; REGL; PSPS2; REGI-BETA

Gene ID: 5968 | Gene type: protein coding

About REG1B

Cytogenetic location: 2p12 Genomic coordinates (GRCh38): 2:79,085,023-79,087,993 (from NCBI)

This gene has 5 transcripts (splice variants), 934 orthologues and 5 paralogues. Biased expression in duodenum (RPKM 280.8), small intestine (RPKM 149.9) and 2 other tissues.

Summary

This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein secreted by the exocrine pancreas that is highly similar to the REG1A protein. The related REG1A protein is associated with islet cell regeneration and diabetogenesis, and may be involved in pancreatic lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]

REG1B Products(1)

mRNA	Protein	Name
NM_006507.4	NP_006498.1	lithostathine-1-beta precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

REG1B Protein Structure

Lectin_C

0
100
166 a.a.

Protein Preferred Names

Protein Names

lithostathine-1-beta

PSP-2

REG1B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	REG1B	P48304	REG1A	Homo sapiens	P05451	Anti Tag CoIP	28514442
Intra	REG1B	P48304	REG1A	Homo sapiens	P05451	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant REG1B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76565	REG-1 beta/REG1B Protein, Human (HEK293, His)	P48304 (Q23-N166)	≥95%

Related Diseases

Diseases

Alias

Pancreatitis

Mumps Pancreatitis

Anaerobic Pneumonia

Pneumonia Due To Anaerobes

Amebiasis

Amoebiasis	Entamoebiasis
Chronic Intestinal Amebiasis	Amoebiasis, Unspecified
Amebic Colitis	Amoebic Enteritis
Infection Due To Entamoeba Histolytica	Amoebic Infection
Disease Due To Endamoebidae	Amoebiasis Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11819	REG1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	REG1B	NCBI	NCBI:711725
Others	REG1B	NCBI

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