RGS12 - regulator of G protein signaling 12 Gene

Homo sapiens

Gene ID: 6002 | Gene type: protein coding

About RGS12

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:3,285,891-3,439,913 (from NCBI)

This gene has 26 transcripts (splice variants), 142 orthologues and 23 paralogues. Ubiquitous expression in skin (RPKM 3.7), brain (RPKM 3.2) and 24 other tissues.

Summary

This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]

RGS12 Products(12)

mRNA	Protein	Name
NM_001394154.1	NP_001381083.1	regulator of G-protein signaling 12 isoform 1
NM_001394155.1	NP_001381084.1	regulator of G-protein signaling 12 isoform 1
NM_001394156.1	NP_001381085.1	regulator of G-protein signaling 12 isoform 2
NM_001394157.1	NP_001381086.1	regulator of G-protein signaling 12 isoform 4
NM_001394158.1	NP_001381087.1	regulator of G-protein signaling 12 isoform 5
NM_001394159.1	NP_001381088.1	regulator of G-protein signaling 12 isoform 6
NM_001394161.1	NP_001381090.1	regulator of G-protein signaling 12 isoform 7
NM_001394162.1	NP_001381091.1	regulator of G-protein signaling 12 isoform 7
NM_001394163.1	NP_001381092.1	regulator of G-protein signaling 12 isoform 7
NM_002926.5	NP_002917.1	regulator of G-protein signaling 12 isoform 2
NM_198227.2	NP_937870.1	regulator of G-protein signaling 12 isoform 3
NM_198229.3	NP_937872.1	regulator of G-protein signaling 12 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase regulator activity	IDA IDA: Inferred from direct assay	9651375	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGS12 Protein Structure

PDZ

RGS

RBD

GoLoco

0
300
600
900
1200
1376 a.a.

Protein Preferred Names

Protein Names

regulator of G-protein signaling 12

regulator of G-protein signalling 12

RGS12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RGS12	O14924	PM20D2	Homo sapiens	Q8IYS1	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mosaic Variegated Aneuploidy Syndrome

Warburton-Anyane-Yeboa Syndrome	Mva Syndrome
Mosaic Variegated Aneuplody Microcephaly Syndrome	Warburton Anyane Yeboa Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11905	RGS12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RGS12	VGNC	VGNC:100266
Mus musculus	RGS12	MGD	MGI:1918979
Canis familiaris	RGS12	VGNC	VGNC:45522
Felis catus	RGS12	VGNC	VGNC:69312
Rattus norvegicus	RGS12	RGD	RGD:3564

Name
Email *

	Sorry, but the email address you supplied was invalid.