RLF - RLF zinc finger Gene

Homo sapiens

Also known as ZN-15L; ZNF292L

Gene ID: 6018 | Gene type: protein coding

About RLF

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:40,161,387-40,240,921 (from NCBI)

This gene has 1 transcript (splice variant), 214 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 13.7), testis (RPKM 7.9) and 25 other tissues.

Summary

Predicted to enable DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within histone H3-K4 monomethylation and regulation of DNA methylation. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

RLF Products(1)

mRNA	Protein	Name
NM_012421.4	NP_036553.2	zinc finger protein Rlf

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10545207	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RLF Protein Structure

zf-C2H2

zf-C2H2_4

zf-C2H2

zf-C2H2_4

0
300
600
900
1200
1500
1800
1914 a.a.

Protein Preferred Names

Protein Names

zinc finger protein Rlf

Zn-15 related

RLF Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	RLF	Q13129	Q99IB8-PRO_0000045603	Hepatitis C virus	Q99IB8-PRO_0000045603	Y2H	24136289
Cross	RLF	Q13129	Q99IB8-PRO_0000045603	Hepatitis C virus	Q99IB8-PRO_0000045603	Pull Down	24136289

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Left Ventricular Noncompaction

Noncompaction Cardiomyopathy	Left Ventricular Hypertrabeculation
Lvnc	Spongy Myocardium
Isolated Noncompaction Of The Ventricular Myocardium	Left Ventricular Myocardial Noncompaction Cardiomyopathy
Fetal Myocardium	Honeycomb Myocardium
Hypertrabeculation Syndrome	Left Ventricular Non-Compaction
Lvht	Non-Compaction Of The Left Ventricular Myocardium
Ventricular Noncompaction, Left	Non-Compaction Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12007	RLF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RLF	VGNC	VGNC:64647
Bos taurus	RLF	VGNC	VGNC:33990
Canis familiaris	RLF	VGNC	VGNC:45604
Macaca mulatta	RLF	VGNC	VGNC:76699
Rattus norvegicus	RLF	RGD	RGD:1305297
Mus musculus	RLF	MGD	MGI:1924705
Macaca fascicularis	RLF	NCBI	NCBI:102125548
Others	RLF	NCBI

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