Birc2 - baculoviral IAP repeat-containing 2 Gene

Rattus norvegicus

Also known as Api2; rIAP1

Gene ID: 60371 | Gene type: protein coding

About Birc2

Primary_assembly 8: 4,968,842-4,988,732 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 218 orthologues, 8 paralogues and is associated with 13 phenotypes. Biased expression in Adrenal (RPKM 363.4), Thymus (RPKM 214.6) and 9 other tissues.

Summary

Predicted to enable several functions, including FBXO family protein binding activity; chaperone binding activity; and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in response to cAMP; response to ethanol; and response to hypoxia. Located in XY body; membrane raft; and nucleus. Part of protein-containing complex. Human ortholog(s) of this gene implicated in breast Cancer. Orthologous to human BIRC2 (baculoviral IAP repeat containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Birc2 Products(1)

mRNA	Protein	Name
NM_021752.3	NP_068520.2	baculoviral IAP repeat-containing protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	15590916	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in response to cAMP	IEP IEP: Inferred from expression pattern	11849428	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	16687129	RGD
involved in response to hypoxia	IDA IDA: Inferred from direct assay	12023884	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	15371238	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in XY body	IDA IDA: Inferred from direct assay	16343737	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	15590916	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Birc2 Protein Structure

BIR

UBA_BIRC2_3

CARD_BIRC2_BIRC3

RING-HC_BIRC2_3_7

0
100
200
300
400
500
589 a.a.

Protein Preferred Names

Protein Names

baculoviral IAP repeat-containing protein 2

apoptosis inhibitor 2

inhibitor of apoptosis protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50685	A 410099.1		99.3%	Unkown
HY-RS01507	BIRC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01508	Birc2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01509	Birc2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Birc2	NCBI	NCBI:329

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