2. Gene
  3. BIRC2 - baculoviral IAP repeat containing 2 Gene

BIRC2 - baculoviral IAP repeat containing 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as API1; MIHB; HIAP2; RNF48; cIAP1; Hiap-2; c-IAP1

Gene ID: 329 | Gene type: protein coding

About BIRC2

Cytogenetic location: 11q22.2 Genomic coordinates (GRCh38): 11:102,347,214-102,378,670 (from NCBI)

This gene has 13 transcripts (splice variants), 218 orthologues and 7 paralogues. Ubiquitous expression in lymph node (RPKM 16.6), gall bladder (RPKM 15.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of a family of proteins that inhibits Apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits Apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

BIRC2 Products(3)

mRNA Protein Name
NM_001256163.1 NP_001243092.1 baculoviral IAP repeat-containing protein 2 isoform 1
NM_001166.5 NP_001157.1 baculoviral IAP repeat-containing protein 2 isoform 1
NM_001256166.2 NP_001243095.1 baculoviral IAP repeat-containing protein 2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables FBXO family protein binding IPI
IPI: Inferred from physical interaction
16510124 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
22493164 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11084335 GOA
enables protein-folding chaperone binding IPI
IPI: Inferred from physical interaction
18239673 GOA
enables transcription coactivator activity IMP
IMP: Inferred from mutant phenotype
21653699 GOA
enables transferase activity EXP
EXP: Inferred from Experiment
19008929 GOA
enables ubiquitin binding IDA
IDA: Inferred from direct assay
16510124 GOA
enables ubiquitin-protein transferase activity EXP
EXP: Inferred from Experiment
10797013 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
11907583 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
19153467 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
21525013 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IEP
IEP: Inferred from expression pattern
12761501 GOA
involved in positive regulation of protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
21931591 GOA
involved in positive regulation of protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
21931591 GOA
involved in positive regulation of protein monoubiquitination IDA
IDA: Inferred from direct assay
21931591 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
11907583 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
11907583 GOA
involved in regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
21737330 GOA
involved in regulation of cell cycle IDA
IDA: Inferred from direct assay
15665297 GOA
involved in regulation of necroptotic process IMP
IMP: Inferred from mutant phenotype
21737330 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16510124 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15665297 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BIRC2 Protein Structure

BIR

BIR: Inhibitor of Apoptosis domain (49 - 114)

BIR

BIR: Inhibitor of Apoptosis domain (187 - 250)

BIR

BIR: Inhibitor of Apoptosis domain (272 - 336)

CARD

CARD: Caspase recruitment domain (459 - 540)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (568 - 610)

  • 0
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  • 500
  • 618 a.a.
Protein Preferred Names Protein Names

baculoviral IAP repeat-containing protein 2

IAP homolog B

IAP-2

NFR2-TRAF signalling complex protein

RING finger protein 48

RING-type E3 ubiquitin transferase BIRC2

TNFR2-TRAF-signaling complex protein 2

apoptosis inhibitor 1

cellular inhibitor of apoptosis 1

inhibitor of apoptosis protein 2

BIRC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
BIRC2 Q13490 BOLA1 Homo sapiens Q9Y3E2
Y2H Prey Pooling
25416956
Intra
BIRC2 Q13490 BOLA1 Homo sapiens Q9Y3E2
Validated Y2H
25416956
Intra
BIRC2 Q13490 BOLA1 Homo sapiens Q9Y3E2
Validated Y2H
32296183
Intra
BIRC2 Q13490 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
BIRC2 Q13490 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
BIRC2 Q13490 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
BIRC2 Q13490 OTUB1 Homo sapiens Q96FW1
Anti Bait CoIP
23524849
Intra
BIRC2 Q13490 OTUB1 Homo sapiens Q96FW1
Anti Tag CoIP
23524849
Intra
BIRC2 Q13490 TCAF1 Homo sapiens Q9Y4C2-2
Validated Y2H
32296183
Intra
BIRC2 Q13490 EAF2 Homo sapiens Q96CJ1
Validated Y2H
25416956
Intra
BIRC2 Q13490 EAF2 Homo sapiens Q96CJ1
Y2H Prey Pooling
25416956
Intra
BIRC2 Q13490 RIPK3 Homo sapiens Q9Y572
Anti Tag CoIP
21931591
Intra
BIRC2 Q13490 RIPK3 Homo sapiens Q9Y572
Pull Down
21931591
Intra
BIRC2 Q13490 RIPK3 Homo sapiens Q9Y572
Enzymatic Study
21931591
Intra
BIRC2 Q13490 TRAF2 Homo sapiens Q12933
PLA
25241761
Intra
BIRC2 Q13490 TRAF2 Homo sapiens Q12933
Anti Bait CoIP
16282325
Intra
BIRC2 Q13490 TRAF2 Homo sapiens Q12933
Anti Tag CoIP
33961781
Intra
BIRC2 Q13490 TRAF2 Homo sapiens Q12933
Y2H Pooling
16189514
Intra
BIRC2 Q13490 TRAF2 Homo sapiens Q12933
Pull Down
16282325
Intra
BIRC2 Q13490 TRAF2 Homo sapiens Q12933
Anti Tag CoIP
23524849
Intra
BIRC2 Q13490 TRAF2 Homo sapiens Q12933
ViroTrap
30561431
Intra
BIRC2 Q13490 TRAF2 Homo sapiens Q12933
Anti Tag CoIP
16282325
Intra
BIRC2 Q13490 RIPK1 Homo sapiens Q13546
ViroTrap
30561431
Intra
BIRC2 Q13490 RIPK1 Homo sapiens Q13546
Pull Down
21931591
Intra
BIRC2 Q13490 RIPK1 Homo sapiens Q13546
Enzymatic Study
21931591
Intra
BIRC2 Q13490 RIPK1 Homo sapiens Q13546
Anti Tag CoIP
21931591
Intra
BIRC2 Q13490 RIPK2 Homo sapiens O43353
Pull Down
21931591
Intra
BIRC2 Q13490 RIPK2 Homo sapiens O43353
Enzymatic Study
21931591
Intra
BIRC2 Q13490 TRAF1 Homo sapiens Q13077
ViroTrap
30561431
Intra
BIRC2 Q13490 TRAF1 Homo sapiens Q13077
Anti Tag CoIP
33961781
Intra
BIRC2 Q13490 TRAF1 Homo sapiens Q13077
Anti Tag CoIP
28514442
Intra
BIRC2 Q13490 TRAF1 Homo sapiens Q13077
Anti Tag CoIP
23524849
Intra
BIRC2 Q13490 EXOSC5 Homo sapiens Q9NQT4
Validated Y2H
25416956
Intra
BIRC2 Q13490 EXOSC5 Homo sapiens Q9NQT4
Validated Y2H
32296183
Intra
BIRC2 Q13490 EXOSC5 Homo sapiens Q9NQT4
Y2H Array
25416956
Intra
BIRC2 Q13490 EXOSC5 Homo sapiens Q9NQT4
Y2H Prey Pooling
25416956
Intra
BIRC2 Q13490 PPM1K Homo sapiens Q8N3J5
Validated Y2H
32296183
Intra
BIRC2 Q13490 PPM1K Homo sapiens Q8N3J5
Y2H Array
25416956
Intra
BIRC2 Q13490 NXF1 Homo sapiens Q9UBU9
Validated Y2H
32296183
Intra
BIRC2 Q13490 RAC1 Homo sapiens P63000
Pull Down
22117219
Intra
BIRC2 Q13490 RIPK4 Homo sapiens P57078
Pull Down
21931591
Intra
BIRC2 Q13490 RIPK4 Homo sapiens P57078
Enzymatic Study
21931591
Intra
BIRC2 Q13490 RIPK4 Homo sapiens P57078
Anti Tag CoIP
21931591
Intra
BIRC2 Q13490 CASP9 Homo sapiens P55211
Validated Y2H
25416956
Intra
BIRC2 Q13490 CASP9 Homo sapiens P55211
Y2H Array
25416956
Intra
BIRC2 Q13490 CASP9 Homo sapiens P55211
Y2H Array
31515488
Intra
BIRC2 Q13490 CASP9 Homo sapiens P55211
Y2H Prey Pooling
25416956
Intra
BIRC2 Q13490 CASP9 Homo sapiens P55211
SPR
19153467
Intra
BIRC2 Q13490 HTRA2 Homo sapiens O43464
Anti Tag CoIP
33961781
Intra
BIRC2 Q13490 HTRA2 Homo sapiens O43464
Anti Tag CoIP
11583623
Intra
BIRC2 Q13490 DIABLO Homo sapiens Q9NR28
Anti Tag CoIP
33961781
Intra
BIRC2 Q13490 DIABLO Homo sapiens Q9NR28
CoIP
10929712
Intra
BIRC2 Q13490 DIABLO Homo sapiens Q9NR28
SPR
19153467
Intra
BIRC2 Q13490 DIABLO Homo sapiens Q9NR28
Pull Down
16282325
Intra
BIRC2 Q13490 BIRC7 Homo sapiens Q96CA5
Y2H Array
25416956
Intra
BIRC2 Q13490 BIRC7 Homo sapiens Q96CA5
Y2H Array
31515488
Intra
BIRC2 Q13490 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
BIRC2 Q13490 NTAQ1 Homo sapiens Q96HA8
Y2H Array
31515488
Intra
BIRC2 Q13490 NTAQ1 Homo sapiens Q96HA8
Y2H Prey Pooling
25416956
Intra
BIRC2 Q13490 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
25416956
Intra
BIRC2 Q13490 TSGA10 Homo sapiens Q9BZW7
Y2H Array
25416956
Intra
BIRC2 Q13490 TSGA10 Homo sapiens Q9BZW7
Y2H
21516116
Intra
BIRC2 Q13490 GCC1 Homo sapiens Q96CN9
Y2H Prey Pooling
25416956
Intra
BIRC2 Q13490 GCC1 Homo sapiens Q96CN9
Validated Y2H
25416956
Intra
BIRC2 Q13490 GCC1 Homo sapiens Q96CN9
Validated Y2H
32296183
Intra
BIRC2 Q13490 GCC1 Homo sapiens Q96CN9
Y2H Array
25416956
Intra
BIRC2 Q13490 NMB Homo sapiens P08949
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

BIRC2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82755 cIAP1 Antibody (YA2500) WB, ICC/IF Human

Related Diseases

Diseases Alias
Squamous Cell Carcinoma

Epidermoid Carcinoma

Squamous Cell Cancer

Carcinoma, Squamous Cell

Malignant Squamous Cell Tumor

Squamous Carcinoma

Squamous Cell Epithelioma

Squamous Cell Skin Cancer

Carcinoma Squamous Cell

Neoplasms, Squamous Cell

Squamous Cell Carcinoma - Category

Malignant Squamous Cell Neoplasm

Squamous Cell Carcinoma Of Skin
Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

NHL

Lymphoma, Non-Hodgkin, Somatic

Lymphoma, Follicular, Somatic

Familial Non-Hodgkin Lymphoma

Lymphoma Non-Hodgkins

Follicular Lymphoma, Somatic

Lymphosarcoma

Non-Hodgkins Lymphoma
Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell
Follicular Lymphoma

Lymphoma, Follicular

Lymphoma Follicular

Brill-Symmers' Disease

Large Cell Follicular Non-Hodgkin Lymphoma

Diffuse Follicle Centre Lymphoma

Diffuse Follicular Lymphoma Nos

Follicular Nodular Non-Hodgkin Lymphoma, Unspecified

Follicular Large Cell Cleaved Or Noncleaved Lymphoma

Large Cell Follicular Noncleaved Lymphoma

Follicular Lymphoma With Or Without Diffuse Areas

Histiocytic Follicular Lymphoma

Histiocytic Nodular Lymphoma

Histiocytic Nodular Malignant Lymphoma

Large Cell Follicular Lymphoma

Large Cell Noncleaved Follicular Lymphoma

Large Cell Noncleaved Follicular Malignant Lymphoma

Nodular Reticulum Cell Sarcoma

Noncleaved Follicular Lymphoma
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma

Gastric Lymphoma, Primary

Lymphoma, Malt, Somatic

Mucosa-Associated Lymphoid Tissue Lymphoma

Extranodal Marginal Zone B-Cell Lymphoma

MALTOMA

Marginal Zone B-Cell Lymphoma

Mucosa-Associated Lymphatic Tissue Lymphoma

Primary Gastric Lymphoma

Gastric Lymphoma

Familial Primary Gastric Lymphoma
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Myeloma, Multiple

Multiple Myeloma

Kahler Disease

Myelomatosis

Plasma Cell Myeloma

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler'S Disease

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
B-Cell Lymphoma

Lymphoma, B-Cell

B-Cell Lymphomas

B-Cell Lymphocytic Neoplasm

Lymphoma B-Cell

B-Cell Lymphoma Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50685 A 410099.1 Inhibitor 99.30% Unkown
HY-RS01507 BIRC2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01508 Birc2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01509 Birc2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BIRC2 MGD MGI:1197009
Macaca mulatta BIRC2 VGNC VGNC:97740
Bos taurus BIRC2 VGNC VGNC:26499
Canis familiaris BIRC2 VGNC VGNC:38460
Rattus norvegicus BIRC2 RGD RGD:620690
Felis catus BIRC2 VGNC VGNC:81907
Others BIRC2 NCBI