RNASE6 - ribonuclease A family member k6 Gene

Homo sapiens

Also known as RAD1; RNS6; RNasek6

Gene ID: 6039 | Gene type: protein coding

About RNASE6

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,781,070-20,782,467 (from NCBI)

This gene has 1 transcript (splice variant), 91 orthologues and 12 paralogues. Broad expression in lymph node (RPKM 33.5), appendix (RPKM 26.6) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014]

RNASE6 Products(1)

mRNA	Protein	Name
NM_005615.5	NP_005606.1	ribonuclease K6 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA nuclease activity	IDA IDA: Inferred from direct assay	9826755	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antibacterial humoral response	IDA IDA: Inferred from direct assay	25075772	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	25075772	GOA
involved in defense response to Gram-negative bacterium	IDA IDA: Inferred from direct assay	25075772	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	25075772	GOA
NOT involved in defense response to virus	IDA IDA: Inferred from direct assay	9826755	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	9826755	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	25075772	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	25075772	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	25075772	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNASE6 Protein Structure

RnaseA

0
100
150 a.a.

Protein Preferred Names

Protein Names

ribonuclease K6

ribonuclease A D1

Recombinant RNASE6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71261	RNASE6 Protein, Human (HEK293, His)	Q93091 (W24-L150)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12022	RNASE6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RNASE6	RGD	RGD:1303020
Bos taurus	RNASE6	VGNC	VGNC:33999
Mus musculus	RNASE6	MGD	MGI:1925666
Macaca mulatta	RNASE6	VGNC	VGNC:76701
Others	RNASE6	NCBI

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