S1pr5 - sphingosine-1-phosphate receptor 5 Gene

Rattus norvegicus

Also known as Edg8; Edg-8

Gene ID: 60399 | Gene type: protein coding

About S1pr5

Primary_assembly 8: 19,786,663-19,791,795 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 236 orthologues, 18 paralogues and is associated with 2 phenotypes. Biased expression in Brain (RPKM 55.), Lung (RPKM 18.2) and 4 other tissues.

Summary

Enables G protein-coupled receptor activity. Involved in regulation of neuron differentiation. Is integral component of membrane. Orthologous to human S1PR5 (sphingosine-1-phosphate receptor 5). [provided by Alliance of Genome Resources, Apr 2022]

S1pr5 Products(1)

mRNA	Protein	Name
NM_021775.2	NP_068543.2	sphingosine 1-phosphate receptor 5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	10799507	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of neuron differentiation	IEP IEP: Inferred from expression pattern	12617946	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S1pr5 Protein Structure

7tm_GPCRs

0
100
200
300
400 a.a.

Protein Preferred Names

Protein Names

sphingosine 1-phosphate receptor 5

NRG-1	S1P receptor 5
S1P receptor Edg-8	S1P5
endothelial differentiation G-protein-coupled receptor 8	endothelial differentiation, sphingolipid G-protein-coupled receptor, 8
nerve growth factor-regulated G-protein-coupled receptor 1	sphingosine 1-phosphate receptor Edg-8

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12355	Siponimod	Agonist	99.95%	Yes
HY-12288	Ozanimod	Agonist	99.88%	Yes
HY-10569	Ponesimod	Agonist	99.81%	Yes
HY-12288A	Ozanimod hydrochloride	Modulator	99.19%	Yes
HY-12355A	Siponimod hemifumarate	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-17606	Cenerimod	Agonist	99.43%	Phase 3

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136578	RP101988	Agonist	98.92%	Unkown
HY-111253	CYM-5478	Agonist	99.90%	Unkown
HY-148198	S1P5 receptor agonist-1	Agonist	/	Unkown
HY-136576	RP101075	Agonist	/	Unkown
HY-148115	S1p receptor agonist 2	Agonist	/	Unkown
HY-136577	RP101442	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	S1pr5	NCBI	NCBI:53637

Name
Email *

	Sorry, but the email address you supplied was invalid.