2. Gene
  3. RNF6 - ring finger protein 6 Gene

RNF6 - ring finger protein 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 6049 | Gene type: protein coding

About RNF6

Cytogenetic location: 13q12.13 Genomic coordinates (GRCh38): 13:26,132,115-26,223,085 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 18.5), brain (RPKM 11.7) and 25 other tissues.

Summary

The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008]

RNF6 Products(4)

mRNA Protein Name
NM_005977.4 NP_005968.1 E3 ubiquitin-protein ligase RNF6 isoform 1
NM_183043.3 NP_898864.1 E3 ubiquitin-protein ligase RNF6 isoform 1
NM_183044.3 NP_898865.1 E3 ubiquitin-protein ligase RNF6 isoform 1
NM_183045.1 NP_898866.1 E3 ubiquitin-protein ligase RNF6 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables nuclear androgen receptor binding IPI
IPI: Inferred from physical interaction
19345326 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19345326 GOA
enables ubiquitin-protein transferase activity IMP
IMP: Inferred from mutant phenotype
19345326 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19345326 GOA
involved in protein K27-linked ubiquitination IDA
IDA: Inferred from direct assay
19345326 GOA
involved in protein K6-linked ubiquitination IDA
IDA: Inferred from direct assay
19345326 GOA
involved in regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19345326 GOA
involved in regulation of androgen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19345326 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19345326 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19345326 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF6 Protein Structure

zf-RING_2

zf-RING_2: Ring finger domain (632 - 673)

  • 0
  • 200
  • 400
  • 600
  • 685 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF6

RING-H2 protein RNF-6

RNF6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RNF6 Q9Y252 AR Homo sapiens P10275
Confocal
19345326
Intra
RNF6 Q9Y252 AR Homo sapiens P10275
CH-IP
19345326
Intra
RNF6 Q9Y252 AR Homo sapiens P10275
Anti Bait CoIP
19345326
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus
Esophagus Squamous Cell Carcinoma

Esophageal Squamous Cell Carcinoma

Oesophagus Squamous Cell Carcinoma

Scc Of Esophagus

Scc Of Oesophagus

Squamous Cell Carcinoma Of The Esophagus

Escc

Esophageal Epidermoid Carcinoma

Squamous Cell Esophageal Cancer

Squamous Cell Carcinoma Of Esophagus
Squamous Cell Carcinoma

Epidermoid Carcinoma

Squamous Cell Cancer

Carcinoma, Squamous Cell

Squamous Cell Skin Cancer

Malignant Squamous Cell Tumor

Squamous Carcinoma

Squamous Cell Epithelioma

Carcinoma Squamous Cell

Neoplasms, Squamous Cell

Squamous Cell Carcinoma - Category

Malignant Squamous Cell Neoplasm

Squamous Cell Carcinoma Of Skin
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12095 RNF6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RNF6 VGNC VGNC:34071
Felis catus RNF6 VGNC VGNC:64706
Canis familiaris RNF6 VGNC VGNC:45674
Macaca mulatta RNF6 VGNC VGNC:82225
Mus musculus RNF6 MGD MGI:1921382
Rattus norvegicus RNF6 RGD RGD:1306092