BCL7A - BAF chromatin remodeling complex subunit BCL7A Gene

Homo sapiens

Also known as BCL7; SMARCJ1

Gene ID: 605 | Gene type: protein coding

About BCL7A

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:122,021,884-122,062,044 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 222 orthologues, 2 paralogues and is associated with 56 phenotypes. Ubiquitous expression in brain (RPKM 10.8), lymph node (RPKM 10.6) and 25 other tissues.

Summary

This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

BCL7A Products(2)

mRNA	Protein	Name
NM_001024808.3	NP_001019979.1	B-cell CLL/lymphoma 7 protein family member A isoform b
NM_020993.5	NP_066273.1	B-cell CLL/lymphoma 7 protein family member A isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SWI/SNF complex	IDA IDA: Inferred from direct assay	23644491	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCL7A Protein Structure

BCL_N

0
100
210 a.a.

Protein Preferred Names

Protein Names

B-cell CLL/lymphoma 7 protein family member A

B-cell CLL/lymphoma 7A

BCL7A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BCL7A	Q4VC05	ALAS1	Homo sapiens	P13196	Y2H Prey Pooling	25416956
Intra	BCL7A	Q4VC05	ALAS1	Homo sapiens	P13196	Validated Y2H	25416956
Intra	BCL7A	Q4VC05	ALAS1	Homo sapiens	P13196	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

B-Cell Non-Hodgkin Lymphoma

B-Cell Nhl

B-Cell Non-Hodgkins Lymphoma

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

Williams-Beuren Syndrome

Williams Syndrome	WBS
Wms	Deletion 7q11.23
Monosomy 7q11.23	Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb
Fanconi Schlesinger Syndrome	Beuren Syndrome
Elfin Facies Syndrome	Elfin Facies With Hypercalcemia
Hypercalcemia-Supravalvar Aortic Stenosis	Ws

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01440	BCL7A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	BCL7A	VGNC	VGNC:107696
Canis familiaris	BCL7A	VGNC	VGNC:38412
Bos taurus	BCL7A	VGNC	VGNC:53891
Mus musculus	BCL7A	MGD	MGI:1924295
Macaca mulatta	BCL7A	VGNC	VGNC:70038
Rattus norvegicus	BCL7A	RGD	RGD:1585128

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