Il1rn - interleukin 1 receptor antagonist Gene

Rattus norvegicus

Also known as IL-1ra

Gene ID: 60582 | Gene type: protein coding

About Il1rn

Summary

Enables interleukin-1 receptor binding activity. Involved in several processes, including cellular response to norepinephrine stimulus; chronic inflammatory response to antigenic stimulus; and fever generation. Located in extracellular space. Used to study adult respiratory distress syndrome; anti-basement membrane glomerulonephritis; hypertension; silicosis; and transient cerebral ischemia. Biomarker of encephalitis and pneumonia. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to human IL1RN (interleukin 1 receptor antagonist). [provided by Alliance of Genome Resources, Apr 2022]

Il1rn Products(1)

mRNA	Protein	Name
NM_022194.2	NP_071530.1	interleukin-1 receptor antagonist protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables interleukin-1 receptor binding	IDA IDA: Inferred from direct assay	1834644	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in carboxylic acid metabolic process	IEP IEP: Inferred from expression pattern	9685640	RGD
involved in cellular response to norepinephrine stimulus	IEP IEP: Inferred from expression pattern	19818755	RGD
involved in chronic inflammatory response to antigenic stimulus	IEP IEP: Inferred from expression pattern	15050649	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	14603373	RGD
involved in fever generation	IMP IMP: Inferred from mutant phenotype	16455768	RGD
involved in memory	IMP IMP: Inferred from mutant phenotype	15050649	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16038625	RGD
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	21244430	RGD
involved in negative regulation of glutamate secretion	IMP IMP: Inferred from mutant phenotype	12667655	RGD
involved in negative regulation of membrane potential	IDA IDA: Inferred from direct assay	20554014	RGD
involved in positive regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	12667655	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	22117073	RGD
involved in response to interleukin-1	IEP IEP: Inferred from expression pattern	8906613	RGD
involved in response to interleukin-4	IEP IEP: Inferred from expression pattern	8409406	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	17138728	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	15751073	RGD
involved in response to starvation	IEP IEP: Inferred from expression pattern	22117073	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	15837124	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	17138728	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interleukin-1 receptor antagonist protein

IL-1RN	IL1 inhibitor
IRAP

Recombinant Il1rn Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73187	IL-1RA/IL-1RN Protein, Rat (HEK293, Fc)	P25086 (H27-Q178)	≥95%
HY-P73894	IL-1RA/IL-1RN Protein, Rat (His, solution)	P25086 (H27-Q178)	≥95%
HY-P75853	IL-1RA/IL-1RN Protein, Cynomolgus (His)	NP_001270468.1 (R26-E177)	≥95%
HY-P73894A	IL-1RA/IL-1RN Protein, Rat (C-His)	P25086 (H27-Q178)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06727	IL1RN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il1rn	NCBI	NCBI:3557
Macaca fascicularis	Il1rn	NCBI	NCBI:102126145
Mus musculus	Il1rn	NCBI	NCBI:16181

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