2. Gene
  3. Lif - LIF, interleukin 6 family cytokine Gene

Lif - LIF, interleukin 6 family cytokine Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 60584 | Gene type: protein coding

About Lif

Summary

Enables Leukemia Inhibitory Factor receptor binding activity. Involved in several processes, including negative regulation of angiogenesis; positive regulation of corticotropin secretion; and transdifferentiation. Located in extracellular space. Biomarker of brain ischemia and congestive heart failure. Orthologous to human LIF (LIF interleukin 6 family cytokine). [provided by Alliance of Genome Resources, Apr 2022]

Lif Products(1)

mRNA Protein Name
NM_022196.3 NP_071532.2 leukemia inhibitory factor precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables leukemia inhibitory factor receptor binding IMP
IMP: Inferred from mutant phenotype
14638908 RGD
Biological Process GO Annotation Evidence Reference Source
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
16369772 RGD
involved in animal organ regeneration IMP
IMP: Inferred from mutant phenotype
14638908 RGD
involved in astrocyte differentiation IMP
IMP: Inferred from mutant phenotype
17328769 RGD
involved in negative regulation of angiogenesis IDA
IDA: Inferred from direct assay
16643897 RGD
involved in positive regulation of corticotropin secretion IDA
IDA: Inferred from direct assay
20160138 RGD
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
18679704 RGD
involved in retina development in camera-type eye IDA
IDA: Inferred from direct assay
16643897 RGD
involved in transdifferentiation IMP
IMP: Inferred from mutant phenotype
20051627 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
20160138 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leukemia inhibitory factor

cholinergic neuronal differentiation factor

leukemia inhibitory factor (cholinergic differentiation factor)

Recombinant Lif Proteins

Cat. No. Product Name Accession Purity
HY-P78621 LIF Protein, Rat (HEK293, His) P17777 (S23-F202) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-120142 EC359 Inducer 99.09% Unkown
HY-D0974 Sulforhodamine B sodium salt 99.28% Unkown
HY-D1603 BODIPY FL-EDA 99.23% Unkown
HY-RS07640 LIF Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lif NCBI NCBI:3976
Macaca fascicularis Lif NCBI NCBI:102129162
Mus musculus Lif NCBI NCBI:16878
Macaca mulatta Lif NCBI NCBI:715456