Gsk3a - glycogen synthase kinase 3 alpha Gene

Mus musculus

Also known as 2700086H06Rik

Gene ID: 606496 | Gene type: protein coding

About Gsk3a

Chromosome 7: 24,927,683-24,937,276 reverse strand.GRCm39:CM001000.3

This gene has 3 transcripts (splice variants), 260 orthologues, 1 paralogue and is associated with 42 phenotypes. Ubiquitous expression in thymus adult (RPKM 12.9), duodenum adult (RPKM 75.3) and 28 other tissues.

Summary

Enables protein serine/threonine kinase activity and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of G protein-coupled receptor signaling pathway; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to lithium ion; positive regulation of protein phosphorylation; and protein phosphorylation. Predicted to be located in microtubule. Predicted to be active in axon; cytosol; and nucleus. Is expressed in several structures, including central nervous system; cranium; early conceptus; tongue; and upper jaw. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human GSK3A (glycogen synthase kinase 3 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Gsk3a Products(2)

mRNA	Protein	Name
NM_001031667.1	NP_001026837.1	glycogen synthase kinase-3 alpha
NM_001031667.1	NP_001026837.1	glycogen synthase kinase-3 alpha

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16051150	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	14730361	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	17986005	MGI
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	16543145	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	20371704	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of positive effect autosome genomic imprinting	IMP IMP: Inferred from mutant phenotype	21047779	MGI
involved in cardiac left ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	20516643	MGI
acts upstream of or within cell migration	IGI IGI: Inferred from genetic interaction	17986005	MGI
involved in cellular response to glucocorticoid stimulus	IGI IGI: Inferred from genetic interaction	20371704	MGI
involved in cellular response to interleukin-3	IDA IDA: Inferred from direct assay	16543145	MGI
acts upstream of or within cellular response to lithium ion	IDA IDA: Inferred from direct assay	15673614	MGI
acts upstream of or within cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	12055200	MGI
involved in extrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	20371704	MGI
involved in extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	16543145	MGI
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	18285345	MGI
involved in negative regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	20516643	MGI
involved in negative regulation of cell growth involved in cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	20516643	MGI
acts upstream of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	17986005	MGI
involved in peptidyl-serine phosphorylation	IGI IGI: Inferred from genetic interaction	16537926	MGI
involved in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20516643	MGI
involved in positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20516643	MGI
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	22539723	MGI
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	20371704	MGI
involved in positive regulation of glycogen (starch) synthase activity	IMP IMP: Inferred from mutant phenotype	20516643	MGI
involved in positive regulation of heart contraction	IMP IMP: Inferred from mutant phenotype	20516643	MGI
involved in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	16543145	MGI
acts upstream of or within positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	17986005	MGI
acts upstream of or within positive regulation of peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	17986005	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21047779	MGI
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	16543145	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	14730361	MGI
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	16543145	MGI
involved in regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	20516643	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gsk3a Protein Structure

STKc_GSK3

0
100
200
300
400
490 a.a.

Protein Preferred Names

Protein Names

glycogen synthase kinase-3 alpha

GSK-3 alpha

serine/threonine-protein kinase GSK3A

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-122665	HTH-01-091	Inhibitor	98.64%	Unkown
HY-122665A	HTH-01-091 TFA	Inhibitor	99.48%	Unkown
HY-W969907	GSK3-IN-7		99.35%	Unkown
HY-RS05862	GSK3A Human Pre-designed siRNA Set A		/	Unkown
HY-RS05863	Gsk3a Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS05864	Gsk3a Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gsk3a	NCBI	NCBI:2931

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