1. Gene
  2. GSK3A - glycogen synthase kinase 3 alpha Gene

GSK3A - glycogen synthase kinase 3 alpha Gene

Homo sapiens
Gene ID: 2931 | Gene type: protein coding

About GSK3A

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,230,190-42,242,602 (from NCBI)

This gene has 40 transcripts (splice variants), 260 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 26.3), testis (RPKM 18.3) and 25 other tissues.

Summary

This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the Wnt and PI3K signaling pathways, as well as regulates the production of beta-amyloid Peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011]

GSK3A Products(2)

mRNA Protein Name
NM_019884.3 NP_063937.2 glycogen synthase kinase-3 alpha
XR_001753673.2

GSK3A Protein Structure

Pkinase

Pkinase: Protein kinase domain (119 - 403)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 483 a.a.
Protein Preferred Names Protein Names

glycogen synthase kinase-3 alpha

GSK-3 alpha

serine/threonine-protein kinase GSK3A

GSK3A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GSK3A P49840 GSKIP Homo sapiens Q9P0R6 35271311
Intra
GSK3A P49840 GSKIP Homo sapiens Q9P0R6
TAP
23602568
Intra
GSK3A P49840 FBXO42 Homo sapiens Q6P3S6
Y2H
30824926
Intra
GSK3A P49840 HSP90AB1 Homo sapiens P08238
Y2H
30824926
Intra
GSK3A P49840 YWHAE Homo sapiens P62258 36931259
Intra
GSK3A P49840 MAPT Homo sapiens P10636-8 26618561
Intra
GSK3A P49840 FRAT1 Homo sapiens Q92837 33961781
Intra
GSK3A P49840 FRAT1 Homo sapiens Q92837
TAP
23602568
Intra
GSK3A P49840 AXIN2 Homo sapiens Q9Y2T1
TAP
23602568
Intra
GSK3A P49840 AXIN2 Homo sapiens Q9Y2T1
Y2H
30824926
Intra
GSK3A P49840 AXIN2 Homo sapiens Q9Y2T1 33961781
Intra
GSK3A P49840 ZDHHC17 Homo sapiens Q8IUH5 24705354
Intra
GSK3A P49840 ZDHHC17 Homo sapiens Q8IUH5 24705354
Intra
GSK3A P49840 AXIN1 Homo sapiens O15169 33961781
Intra
GSK3A P49840 AXIN1 Homo sapiens O15169
TAP
23602568
Intra
GSK3A P49840 AXIN1 Homo sapiens O15169 17318175
Intra
GSK3A P49840 AXIN1 Homo sapiens O15169 35271311
Intra
GSK3A P49840 DEAF1 Homo sapiens O75398
Y2H
30824926
Intra
GSK3A P49840 DEAF1 Homo sapiens O75398 20368287
Intra
GSK3A P49840 NBR1 Homo sapiens Q14596 33961781
Intra
GSK3A P49840 NBR1 Homo sapiens Q14596 24879152
Intra
GSK3A P49840 NBR1 Homo sapiens Q14596
Y2H
30824926
Intra
GSK3A P49840 NBR1 Homo sapiens Q14596 24879152
Intra
GSK3A P49840 LRP6 Homo sapiens O75581
Y2H
30824926
Intra
GSK3A P49840 LRP6 Homo sapiens O75581 16365045
Intra
GSK3A P49840 LRP6 Homo sapiens O75581 16365045
Cross: Cross-species interaction Intra: Intraspecies interaction

GSK3A Antibodies

Cat. No. Product Name Application Reactivity
HY-P80819 Phospho-GSK3 (Tyr216/Tyr279) Antibody WB, IP Mouse, Rat
HY-P82117 GSK3 alpha/beta Antibody (YA1862) WB Human, Rat, Hamster
HY-P83226 GSK3 alpha Antibody (YA2971) WB, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GSK3A RGD RGD:620351
Mus musculus GSK3A MGD MGI:2152453
Canis familiaris GSK3A VGNC VGNC:101443
Bos taurus GSK3A VGNC VGNC:101449
Felis catus GSK3A VGNC VGNC:101459
Others GSK3A NCBI